Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | THPO | P40225 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | ZDHHC7 | Q9NXF8 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.34 |
| ▸ | CA2 | P00918 | 2/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA3 | P07451 | 1/20 | 0.34 |
| ▸ | CA4 | P22748 | 1/20 | 0.34 |
| ▸ | CA6 | P23280 | 1/20 | 0.34 |
| ▸ | CA5A | P35218 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12064041 | 0.87 | SMN1; SMN2 (0.45) | THRBKDM4EMAPTALOX15NFKB1 | |
| SCHEMBL12064309 | 0.87 | SMN1; SMN2 (0.45) | THRBKDM4EMAPTALOX15NFKB1 | |
| SCHEMBL12064029 | 0.87 | SMN1; SMN2 (0.45) | THRBKDM4EMAPTALOX15NFKB1 | |
| SCHEMBL3732035 | 0.84 | ALDH1A1 (0.36) | THRBALDH1A1ZDHHC7CA1CA2 | |
| SCHEMBL8820895 | 0.83 | SMN1; SMN2 (0.42) | THRBKDM4EMAPTALOX15NFKB1 | |
| SCHEMBL17378386 | 0.83 | GNPAT (0.42) | THRBKDM4EMAPTALOX15NFKB1 | |
| SCHEMBL8234349 | 0.83 | TRPV1 (0.43) | THRBKDM4EMAPTALOX15NFKB1 | |
| SCHEMBL3241409 | 0.82 | TAS1R3 (0.46) | THRBKDM4EMAPTALOX15NFKB1 | |
| SCHEMBL711890 | 0.82 | TAS1R3 (0.46) | THRBKDM4EMAPTALOX15NFKB1 | |
| SCHEMBL5812827 | 0.82 | THRB (0.41) | THRBKDM4EMAPTALOX15NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7544699-B2 | Aryl and heteroaryl compounds, compositions, and methods of use | TRANSTECH PHARMA, INC. (US) | 2009-06-09 | — | — | US | disclosed |
| US-7459472-B2 | Aryl and heteroaryl compounds, compositions, and methods of use | TRANSTECH PHARMA, INC. (US) | 2008-12-02 | — | — | US | disclosed |