SCHEMBL1379817

SCHEMBL1379817

CCc1cccc2[nH][c]nc12

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GABRA1 P14867 4/20 0.38
GABRB2 P47870 4/20 0.38
DAO P14920 1/20 0.36
DDO Q99489 1/20 0.36
TAAR1 Q96RJ0 2/20 0.33
HTR1A P08908 1/20 0.33
NPEPPS P55786 1/20 0.33
PLA2G2A P14555 1/20 0.33
ATP4A P20648 1/20 0.32
ATP4B P51164 1/20 0.32
TLR8 Q9NR97 1/20 0.32
MAPT P10636 2/20 0.32
KDM4E B2RXH2 2/20 0.32
ALDH1A1 P00352 1/20 0.32
PDK2 Q15119 1/20 0.32
ELANE P08246 1/20 0.31
MEN1 O00255 1/20 0.31
POLB P06746 1/20 0.31
KMT2A Q03164 1/20 0.31
KCNH2 Q12809 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7060893 0.83 LIPG (0.33) GABRA1GABRB2TLR8KCNH2
SCHEMBL4737660 0.82
SCHEMBL7213697 0.81
SCHEMBL7616893 0.81 GABRA1 (0.43) GABRA1GABRB2ELANE
SCHEMBL18765144 0.78 GAA (0.43) PLA2G2AKDM4EALDH1A1
SCHEMBL8474445 0.78
SCHEMBL433019 0.77 CYP3A4 (0.42) DAOKDM4EALDH1A1MEN1KMT2A
SCHEMBL1079894 0.77 GABRA1 (0.40) GABRA1GABRB2HTR1AMAPTKDM4E
SCHEMBL2158571 0.76 SLC6A4 (0.36) HTR1AKCNH2
SCHEMBL6032884 0.75 CTRC (0.31) HTR1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 354 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117242066-A Novel compound and organic light emitting device comprising the same 株式会社LG化学 2023-12-15 CN claimed
EP-3174871-A1 BICYCLIC ARYLCARBOXYLIC ACID AMIDES AND THEIR USE AS HERBICIDES Bayer CropScience Aktiengesellschaft (DE) 2017-06-07 EP claimed
WO-2016016107-A1 BICYCLIC ARYLCARBOXYLIC ACID AMIDES AND THEIR USE AS HERBICIDES BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2016-02-04 WO claimed
EP-2903981-A1 1,2,4-TRIAZINE-3,5-DIONE-6-CARBOXAMIDES AND USE THEREOF AS HERBICIDE Bayer CropScience AG (DE) 2015-08-12 EP claimed
EP-2686316-B1 N-(1,2,5-OXADIAZOL-3-YL)PYRIDINECARBOXAMIDES AND USE THEREOF AS HERBICIDES BAYER IP GMBH (DE) 2015-04-22 EP claimed
EP-2844650-A1 6-PYRIDONE-2-CARBAMOYL-AZOLES AND THEIR USE AS HERBICIDES Bayer CropScience AG (DE) 2015-03-11 EP claimed
WO-2015007633-A1 6-AZINONE-2-CARBONYL DERIVATIVES AND THEIR USE AS HERBICIDES BAYER CROPSCIENCE AG (DE) 2015-01-22 WO claimed
WO-2015007632-A1 URACIL-5-CARBOXAMIDES AND THEIR USE AS HERBICIDES BAYER CROPSCIENCE AG (DE) 2015-01-22 WO claimed
WO-2014086737-A1 CONDENSED 2-PYRIDONE-3-CARBOXAMIDES AND THE USE THEREOF AS HERBICIDES BAYER CROPSCIENCE AG (DE) 2014-06-12 WO claimed
WO-2014053473-A1 1,2,4-TRIAZINE-3,5-DIONE-6-CARBOXAMIDES AND USE THEREOF AS HERBICIDE BAYER CROPSCIENCE AG (DE) 2014-04-10 WO claimed
JP-4728259-B2 2011-07-20 JP claimed
US-20070167482-A1 Novel guanidinyl-substituted hydroxy-6-phenylphenanthridines as effective phosphodiesterase (pde) 4 inhibitors ALTANA PHARMA AG (DE) 2007-07-19 US claimed
EP-1720835-A1 NOVEL GUANIDINYL-SUBSTITUTED HYDROXY-6-PHENYLPHENANTHRIDINES AS EFFECTIVE PHOSPHODIESTERASE (PDE) 4 INHIBITORS Altana Pharma AG (DE) 2006-11-15 EP claimed
US-20060116518-A1 Novel phenanthridines ALTANA PHARMA AG (DE) 2006-06-01 US claimed
EP-1581533-A2 NOVEL BENZONAPHTHYRIDINES ALTANA Pharma AG (DE) 2005-10-05 EP claimed
WO-2004018465-A9 BENZONAPHTHYRIDINES WITH PDE 3/4 INHIBITING ACTIVITY ALTANA PHARMA AG (DE) 2005-09-15 WO claimed
WO-2005077906-A1 NOVEL GUANIDINYL-SUBSTITUTED HYDROXY-6-PHENYLPHENENTHRIDINES AS EFFECTIVE PHOSPHODIESTERASE (PDE) 4 INHIBITORS ALTANA PHARMA AG (DE) 2005-08-25 WO claimed
EP-1537086-A2 NOVEL PHENANTHRIDINES ALTANA Pharma AG (DE) 2005-06-08 EP claimed
WO-2004018431-A2 NOVEL PHENANTHRIDINES ALTANA PHARMA AG (DE) 2004-03-04 WO claimed
WO-2004018465-A2 BENZONAPHTHYRIDINES WITH PDE 3/4 INHIBITING ACTIVITY ALTANA PHARMA AG (DE) 2004-03-04 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070167482-A1 Novel guanidinyl-substituted hydroxy-6-phenylphenanthridines as effective phosphodiesterase (pde) 4 inhibitors PDE4A, PDE3A, PDE4B GABRA1 3401/4885GABRB2 3693/4885DAO 1312/4885
US-20060116518-A1 Novel phenanthridines PDE4A, PDE4B, PDE3A GABRA1 3620/4885GABRB2 4096/4885DAO 2829/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.