Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | ATM | Q13315 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ELANE | P08246 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | CUL4A | Q13619 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | AR | P10275 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL269329 | 0.76 | LMNA (0.80) | LMNAGLAMEN1KMT2AMAPT | |
| SCHEMBL4443112 | 0.76 | LMNA (0.55) | LMNAGLAMEN1KMT2AATM | |
| Lithium SCHEMBL30522746 | 0.73 | LMNA (0.76) | LMNAGLAMEN1KMT2AMAPT | |
| SCHEMBL14760365 | 0.73 | LMNA (0.76) | LMNAGLAMEN1KMT2AMAPT | |
| SCHEMBL4865869 | 0.73 | LMNA (0.52) | LMNAGLAMEN1KMT2AATM | |
| SCHEMBL1790363 | 0.73 | LMNA (0.52) | LMNAGLAMEN1KMT2AMAPT | |
| SCHEMBL28863715 | 0.72 | HSD17B10 (0.45) | LMNAGLAMEN1KMT2AATM | |
| SCHEMBL4454162 | 0.72 | LMNA (0.55) | LMNAGLAMEN1KMT2AATM | |
| SCHEMBL4454166 | 0.72 | LMNA (0.55) | LMNAGLAMEN1KMT2AATM | |
| SCHEMBL4454157 | 0.72 | LMNA (0.55) | LMNAGLAMEN1KMT2AATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10799475-B2 | Substituted phenyl aziridine precursor analogs for inhibiting androgen-independent prostate cancer cell growth | NORTHWESTERN UNIVERSITY (US) | 2020-10-13 | — | — | US | disclosed |
| US-20170216249-A1 | Substituted Phenyl Aziridine Precursor Analogs for Inhibiting Androgen-Independent Prostate Cancer Cell Growth | NORTHWESTERN UNIVERSITY (US) | 2017-08-03 | — | — | US | disclosed |
| US-20160089354-A1 | Substituted Phenyl Aziridine Precursor Analogs for Inhibiting Androgen-Independent Cancer Cell Growth | NORTHWESTERN UNIVERSITY (US) | 2016-03-31 | — | — | US | disclosed |
| US-20140045938-A1 | Substituted Phenyl Aziridine Precursor Analogs for Inhibiting Androgen-Independent Prostate Cancer Cell Growth | NORTHWESTERN UNIVERSITY (US) | 2014-02-13 | — | — | US | disclosed |
| US-20090156672-A1 | Substituted Phenyl Aziridine Precursor Analogs as Modulators of Steroid Receptor Activities | NORTHWESTERN UNIVERSITY (US) | 2009-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160089354-A1 | Substituted Phenyl Aziridine Precursor Analogs for Inhibiting Androgen-Independent Cancer Cell Growth | NR5A1, AR, CYP17A1 | LMNA 4562/4885GLA 1983/4885MEN1 3420/4885 |
| US-20170216249-A1 | Substituted Phenyl Aziridine Precursor Analogs for Inhibiting Androgen-Independent Prostate Cancer Cell Growth | NR5A1, AR, CYP17A1 | LMNA 4589/4885GLA 1528/4885MEN1 3105/4885 |
| US-20140045938-A1 | Substituted Phenyl Aziridine Precursor Analogs for Inhibiting Androgen-Independent Prostate Cancer Cell Growth | NR5A1, AR, CYP17A1 | LMNA 4589/4885GLA 1528/4885MEN1 3105/4885 |
| US-20090156672-A1 | Substituted Phenyl Aziridine Precursor Analogs as Modulators of Steroid Receptor Activities | NR5A1, AR, NR3C1 | LMNA 4632/4885GLA 2280/4885MEN1 3585/4885 |
| US-10799475-B2 | Substituted phenyl aziridine precursor analogs for inhibiting androgen-independent prostate cancer cell growth | NR5A1, AR, CYP17A1 | LMNA 4589/4885GLA 1528/4885MEN1 3105/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.