Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1G | O43497 | 1/20 | 0.48 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.48 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.48 |
| ▸ | ELOVL1 | Q9BW60 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CFTR | P13569 | 3/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | EP300 | Q09472 | 1/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3147231 | 0.86 | SIGMAR1 (0.47) | CACNA1GCACNA1HCACNA1IELOVL1ALDH1A1 | |
| SCHEMBL2905503 | 0.80 | CACNA1G (0.52) | CACNA1GCACNA1HCACNA1IELOVL1ALDH1A1 | |
| SCHEMBL4174047 | 0.76 | CACNA1G (0.49) | CACNA1GCACNA1HCACNA1IELOVL1ALDH1A1 | |
| SCHEMBL15371489 | 0.75 | SIGMAR1 (0.43) | CACNA1GCACNA1HCACNA1IALDH1A1SIGMAR1 | |
| SCHEMBL3044827 | 0.75 | CACNA1G (0.48) | CACNA1GCACNA1HCACNA1IELOVL1ALDH1A1 | |
| SCHEMBL2904146 | 0.74 | HPGD (0.48) | CACNA1GCACNA1HCACNA1IELOVL1ALDH1A1 | |
| SCHEMBL2926761 | 0.71 | CACNA1G (0.45) | CACNA1GCACNA1HCACNA1IELOVL1ALDH1A1 | |
| SCHEMBL2921648 | 0.71 | CACNA1G (0.45) | CACNA1GCACNA1HCACNA1IELOVL1ALDH1A1 | |
| SCHEMBL11885452 | 0.70 | ALDH1A1 (0.66) | CACNA1GCACNA1HCACNA1IELOVL1ALDH1A1 | |
| SCHEMBL4117288 | 0.69 | NPC1 (0.60) | CACNA1GCACNA1HCACNA1IELOVL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090143381-A1 | MODULATORS OF ATP-BINDING CASSETTE-TRANSPORTERS | VERTEX PHARMACEUTICALS INCORPORATED | 2009-06-04 | — | — | US | disclosed |
| US-20090143381-A1 | MODULATORS OF ATP-BINDING CASSETTE-TRANSPORTERS | VERTEX PHARMACEUTICALS INCORPORATED | 2009-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090143381-A1 | MODULATORS OF ATP-BINDING CASSETTE-TRANSPORTERS | CFTR, ABCB1, ABCC2 | CACNA1G 2301/4885CACNA1H 2791/4885CACNA1I 2971/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.