SCHEMBL1378359

SCHEMBL1378359

O=C(O)Cc1c[nH]c2cc(OCCCC#Cc3ccc(C(F)(F)F)cc3)ccc12

nearest known ligand 0.43

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
PPARD Q03181 10/20 0.43
PPARA Q07869 9/20 0.43
PPARG P37231 5/20 0.43
KDM4E B2RXH2 1/20 0.40
CDK2 P24941 1/20 0.40
EGLN1 Q9GZT9 1/20 0.39
MCL1 Q07820 1/20 0.39
TSHR P16473 1/20 0.38
AKR1C3 P42330 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1378534 0.91 PPARD (0.41) PPARDPPARAPPARGKDM4ECDK2
SCHEMBL5176038 0.88 PKM (0.44) PPARDPPARAPPARGCDK2MCL1
SCHEMBL1379245 0.83 KDM4E (0.50) PPARDPPARAPPARGKDM4ETSHR
SCHEMBL5177050 0.79 PKM (0.44) PPARDPPARAPPARG
SCHEMBL1380488 0.79 GOT1 (0.43) KDM4ECDK2TSHR
SCHEMBL8180904 0.76 KDM4E (0.56) PPARDPPARAPPARGKDM4ETSHR
SCHEMBL2386812 0.75 ALDH1A1 (0.58) KDM4ECDK2MCL1TSHR
SCHEMBL1383911 0.75 KDM4E (0.41) PPARDPPARAPPARGKDM4ECDK2
SCHEMBL5617384 0.74 PPARD (0.45) PPARDPPARAPPARGKDM4E
SCHEMBL6064761 0.74 AGER (0.40) PPARDPPARAPPARGKDM4EMCL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-4629106-B2 2011-02-09 JP claimed
JP-2008509947-A 2008-04-03 JP claimed
EP-1781608-A1 INDOLE DERIVATIVES COMPRISING AN ACETYLENE GROUP AS PPAR ACTIVATORS F.HOFFMANN-LA ROCHE AG (CH) 2007-05-09 EP claimed
WO-2006018174-A1 INDOLE DERIVATIVES COMPRISING AN ACETYLENE GROUP AS PPAR ACTIVATORS F. HOFFMANN-LA ROCHE AG (CH) 2006-02-23 WO claimed
EP-1781608-A1 INDOLE DERIVATIVES COMPRISING AN ACETYLENE GROUP AS PPAR ACTIVATORS F.HOFFMANN-LA ROCHE AG (CH) 2007-05-09 EP disclosed
WO-2006018174-A1 INDOLE DERIVATIVES COMPRISING AN ACETYLENE GROUP AS PPAR ACTIVATORS F. HOFFMANN-LA ROCHE AG (CH) 2006-02-23 WO disclosed