Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.53 |
| ▸ | THRA | P10827 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.52 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.52 |
| ▸ | RELA | Q04206 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.52 |
| ▸ | CDK1 | P06493 | 1/20 | 0.51 |
| ▸ | TUBB | P07437 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13812693 | 0.91 | THRB (0.53) | THRBMEN1KMT2ATDP1LMNA | |
| SCHEMBL13812597 | 0.91 | THRB (0.58) | THRBMEN1KMT2ATDP1LMNA | |
| SCHEMBL13812599 | 0.91 | TUBB (0.62) | THRBMEN1KMT2ATDP1LMNA | |
| SCHEMBL13812600 | 0.87 | LTA4H (0.61) | THRBMEN1KMT2ATDP1LMNA | |
| SCHEMBL13812609 | 0.85 | TMPRSS4 (0.64) | MEN1KMT2ALMNAHTTMAPT | |
| SCHEMBL13812612 | 0.83 | TUBB (0.55) | THRBMEN1KMT2ATDP1LMNA | |
| SCHEMBL13812638 | 0.81 | NPC1 (0.54) | THRBMEN1KMT2ATDP1LMNA | |
| SCHEMBL13812636 | 0.81 | THRB (0.59) | THRBMEN1KMT2ATDP1LMNA | |
| SCHEMBL23675417 | 0.81 | P2RX1 (0.60) | MEN1KMT2ALMNAGAAMAPT | |
| SCHEMBL13812613 | 0.81 | DNMT3A (0.55) | THRBMEN1KMT2ATDP1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7547804-B2 | Compounds, compositions, and methods employing same | MYRIAD GENETICS, INC. (US) | 2009-06-16 | — | — | US | disclosed |
| US-7547804-B2 | Compounds, compositions, and methods employing same | MYRIAD GENETICS, INC. (US) | 2009-06-16 | — | — | US | disclosed |