Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 3/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.50 |
| ▸ | GSK3B | P49841 | 1/20 | 0.49 |
| ▸ | CDK1 | P06493 | 1/20 | 0.49 |
| ▸ | THRA | P10827 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.47 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13812596 | 0.91 | THRB (0.58) | THRBTDP1LMNAGAAHTT | |
| SCHEMBL13812638 | 0.90 | NPC1 (0.54) | THRBTDP1LMNAGAAHTT | |
| SCHEMBL13812612 | 0.90 | TUBB (0.55) | THRBTDP1LMNAHTTMEN1 | |
| SCHEMBL13812636 | 0.88 | THRB (0.59) | THRBTDP1LMNAGAAHTT | |
| SCHEMBL3863657 | 0.84 | P2RX1 (0.62) | MEN1KMT2ANPC1RAB9ASIRT2 | |
| SCHEMBL13812600 | 0.83 | LTA4H (0.61) | THRBTDP1LMNAGAAHTT | |
| SCHEMBL13812599 | 0.83 | TUBB (0.62) | THRBTDP1LMNAGAAHTT | |
| SCHEMBL13812597 | 0.83 | THRB (0.58) | THRBTDP1LMNAGAAHTT | |
| SCHEMBL13812562 | 0.82 | TMPRSS4 (0.62) | MEN1KMT2ANPC1RAB9ASIRT2 | |
| SCHEMBL13812617 | 0.79 | RAB9A (0.60) | THRBLMNAGAAHTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7547804-B2 | Compounds, compositions, and methods employing same | MYRIAD GENETICS, INC. (US) | 2009-06-16 | — | — | US | disclosed |
| US-7547804-B2 | Compounds, compositions, and methods employing same | MYRIAD GENETICS, INC. (US) | 2009-06-16 | — | — | US | disclosed |