Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMPRSS4 | Q9NRS4 | 6/20 | 0.51 |
| ▸ | P2RX1 | P51575 | 10/20 | 0.50 |
| ▸ | P2RX4 | Q99571 | 2/20 | 0.50 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.50 |
| ▸ | FADS1 | O60427 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GBA1 | P04062 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13812585 | 0.85 | FADS1 (0.61) | TMPRSS4P2RX1P2RX4P2RX7FADS1 | |
| SCHEMBL13812650 | 0.84 | KCNMA1 (0.53) | TMPRSS4P2RX1P2RX4P2RX7FADS1 | |
| SCHEMBL13812680 | 0.83 | MAPT (0.53) | TMPRSS4P2RX1P2RX4P2RX7FADS1 | |
| SCHEMBL13812592 | 0.81 | TMPRSS4 (0.55) | TMPRSS4P2RX1P2RX4P2RX7FADS1 | |
| SCHEMBL13812563 | 0.73 | P2RX1 (0.59) | TMPRSS4P2RX1P2RX4P2RX7FADS1 | |
| SCHEMBL13812671 | 0.72 | KCNMA1 (0.56) | TMPRSS4P2RX1P2RX4P2RX7MEN1 | |
| SCHEMBL13189548 | 0.72 | P2RX1 (0.74) | TMPRSS4P2RX1P2RX4P2RX7NPC1 | |
| SCHEMBL18341186 | 0.72 | LRRK2 (0.60) | TMPRSS4P2RX1P2RX4P2RX7GAA | |
| SCHEMBL538439 | 0.70 | TMPRSS4 (1.00) | TMPRSS4P2RX1P2RX4P2RX7FADS1 | |
| SCHEMBL13189704 | 0.70 | P2RX1 (0.67) | TMPRSS4P2RX1P2RX4P2RX7FADS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7547804-B2 | Compounds, compositions, and methods employing same | MYRIAD GENETICS, INC. (US) | 2009-06-16 | — | — | US | disclosed |
| US-7547804-B2 | Compounds, compositions, and methods employing same | MYRIAD GENETICS, INC. (US) | 2009-06-16 | — | — | US | disclosed |