SCHEMBL538439

SCHEMBL538439

O=C(Nc1ccccc1)c1cc(Cl)ccc1O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
TMPRSS4 Q9NRS4 6/20 1.00
P2RX1 P51575 12/20 0.81
P2RX4 Q99571 5/20 0.79
P2RX7 Q99572 5/20 0.79
KCNMA1 Q12791 3/20 0.72
SLC2A1 P11166 1/20 0.66
FADS1 O60427 1/20 0.65
KDM4E B2RXH2 1/20 0.64
MEN1 O00255 1/20 0.64
LMNA P02545 1/20 0.64
TP53 P04637 1/20 0.64
HPGD P15428 1/20 0.64
HTT P42858 1/20 0.64
KMT2A Q03164 1/20 0.64
HSD17B10 Q99714 1/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18341403 0.93 TMPRSS4 (0.86) TMPRSS4P2RX1P2RX4P2RX7KCNMA1
SCHEMBL29024720 0.91 TMPRSS4 (0.83) TMPRSS4P2RX1P2RX4P2RX7KCNMA1
SCHEMBL2169619 0.90 P2RX1 (1.00) TMPRSS4P2RX1P2RX4P2RX7KCNMA1
SCHEMBL29454776 0.90 P2RX1 (1.00) TMPRSS4P2RX1P2RX4P2RX7KCNMA1
SCHEMBL11932152 0.89 P2RX1 (1.00) TMPRSS4P2RX1P2RX4P2RX7KCNMA1
SCHEMBL13812568 0.88 TMPRSS4 (0.78) TMPRSS4P2RX1P2RX4P2RX7KCNMA1
SCHEMBL329189 0.88 TMPRSS4 (0.78) TMPRSS4P2RX1P2RX4P2RX7KCNMA1
SCHEMBL24438034 0.87 TMPRSS4 (0.76) TMPRSS4P2RX1P2RX4P2RX7KCNMA1
SCHEMBL24438367 0.87 TMPRSS4 (0.76) TMPRSS4P2RX1P2RX4P2RX7KCNMA1
SCHEMBL24438295 0.87 TMPRSS4 (0.76) TMPRSS4P2RX1P2RX4P2RX7KCNMA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 311 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260091043-A1 COMPOSITIONS AND METHODS FOR TREATING MYCOBACTERIUM INFECTIONS DATA2DISCOVERY INC (US) 2026-04-02 US claimed
WO-2024064209-A1 COMPOSITIONS AND METHODS FOR TREATING MYCOBACTERIUM INFECTIONS DATA2DISCOVERY, INC. (US) 2024-03-28 WO claimed
US-20200038350-A1 CHEMICAL MODULATORS OF SIGNALING PATHWAYS AND THERAPEUTIC USE DUKE UNIVERSITY 2020-02-06 US claimed
EP-3313388-A1 CHEMICAL MODULATORS OF SIGNALING PATHWAYS AND THERAPEUTIC USE Duke University (US) 2018-05-02 EP claimed
WO-2016210289-A1 CHEMICAL MODULATORS OF SIGNALING PATHWAYS AND THERAPEUTIC USE DUKE UNIVERSITY (US) 2016-12-29 WO claimed
US-20140221411-A1 2-HYDROXYARYLAMIDE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING CANCER CONTAINING SAME AS ACTIVE INGREDIENT KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY (KR) 2014-08-07 US claimed
US-20070148185-A1 Novel therapeutic target for protozoal diseases VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY 2007-06-28 US claimed
WO-2007047579-A2 A NOVEL THERAPEUTIC TARGET FOR PROTOZOAL DISEASES VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (US) 2007-04-26 WO claimed
EP-1349453-A2 BIOCIDE COMPOSITIONS AND METHODS AND SYSTEMS EMPLOYING SAME THE PROCTER & GAMBLE COMPANY (US) 2003-10-08 EP claimed
US-20020068014-A1 Antibacterial agents and compositions, methods and systems employing same PROCTER & GAMBLE COMPANY, THE 2002-06-06 US claimed
US-20020014178-A1 Biocide compositions and methods and systems employing same PROCTER & GAMBLE COMPANY, THE 2002-02-07 US claimed
WO-2002005643-A2 BIOCIDE COMPOSITIONS AND METHODS AND SYSTEMS EMPLOYING SAME THE PROCTER & GAMBLE COMPANY (US) 2002-01-24 WO claimed
WO-2001060157-A2 ANTIBACTERIAL AGENTS AND COMPOSITIONS THE PROCTER & GAMBLE COMPANY (US) 2001-08-23 WO claimed
US-4983569-A Color-forming layer comprising a fluorene dye chromogen, a developer, an isocyanate and an imino compound; infrared absorption; storage stability; colorfastness MITSUBISHI PAPER MILLS (JP) 1991-01-08 US claimed
US-4845072-A COLORING LAYER COMPRISING A LEUCO DYE, A COLOR DEVELOPER AND A VINYL ETHER COMPOUND RICOH COMPANY, LTD. (JP) 1989-07-04 US claimed
US-4731354-A ARYL DIETHER SOLVENT RICOH COMPANY, LTD. (JP) 1988-03-15 US claimed
JP-59124885-A None JP disclosed
US-20260091043-A1 COMPOSITIONS AND METHODS FOR TREATING MYCOBACTERIUM INFECTIONS DATA2DISCOVERY INC (US) 2026-04-02 US disclosed
EP-0128006-A2 A soil-disease-controlling agent SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1984-12-12 EP disclosed
JP-S59124885-A HEAT-SENSITIVE RECORDING MATERIAL RICOH CO LTD 1984-07-19 JP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020068014-A1 Antibacterial agents and compositions, methods and systems employing same SPOUT1, PGLS, TLR6 TMPRSS4 2344/4885P2RX1 2786/4885P2RX4 2898/4885
US-20260091043-A1 COMPOSITIONS AND METHODS FOR TREATING MYCOBACTERIUM INFECTIONS AHCY, MACO1, ME3 TMPRSS4 2198/4885P2RX1 2635/4885P2RX4 3093/4885
US-20200038350-A1 CHEMICAL MODULATORS OF SIGNALING PATHWAYS AND THERAPEUTIC USE SFRP1, FZD7, WNT1 TMPRSS4 2074/4885P2RX1 3423/4885P2RX4 3784/4885
US-20140221411-A1 2-HYDROXYARYLAMIDE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING CANCER CONTAINING SAME AS ACTIVE INGREDIENT TMPRSS2, TMPRSS4, PRSS2 TMPRSS4 2/4885P2RX1 4273/4885P2RX4 3330/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.