Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.60 |
| ▸ | HPGD | P15428 | 3/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | GLA | P06280 | 1/20 | 0.57 |
| ▸ | APEX1 | P27695 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | PPARG | P37231 | 1/20 | 0.55 |
| ▸ | PPARA | Q07869 | 1/20 | 0.55 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | BRD4 | O60885 | 1/20 | 0.54 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.54 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.54 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13812814 | 0.83 | TUBB (0.63) | LMNAHPGDMAPT | |
| SCHEMBL23657593 | 0.82 | LMNA (0.72) | LMNAHPGDPPARADNMT3A | |
| SCHEMBL13812735 | 0.82 | HPGD (0.65) | LMNAHPGDTP53GLAAPEX1 | |
| SCHEMBL28498838 | 0.82 | HPGD (0.72) | LMNAHPGDTP53GLAAPEX1 | |
| SCHEMBL29809770 | 0.82 | HPGD (0.72) | LMNAHPGDTP53GLAAPEX1 | |
| SCHEMBL3655099 | 0.81 | DNMT3A (0.77) | DNMT3A | |
| SCHEMBL31023473 | 0.81 | HPGD (0.60) | LMNAHPGDTP53GLASMN1; SMN2 | |
| SCHEMBL11706059 | 0.81 | DNMT3A (0.72) | LMNAHPGDPPARGPPARADNMT3A | |
| SCHEMBL31023570 | 0.81 | ROCK2 (0.54) | LMNAHPGDTP53GLAAPEX1 | |
| SCHEMBL3784241 | 0.81 | DNMT3A (0.80) | LMNADNMT3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7547804-B2 | Compounds, compositions, and methods employing same | MYRIAD GENETICS, INC. (US) | 2009-06-16 | — | — | US | disclosed |
| US-7547804-B2 | Compounds, compositions, and methods employing same | MYRIAD GENETICS, INC. (US) | 2009-06-16 | — | — | US | disclosed |