Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.56 |
| ▸ | STAT3 | P40763 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.48 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.47 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.47 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | FADS1 | O60427 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13812750 | 0.90 | FADS1 (0.58) | LRRK2NPC1RAB9AMAPTPOLB | |
| SCHEMBL13812776 | 0.89 | KCNK3 (0.51) | STAT3NPC1RAB9APOLBKMT2A | |
| SCHEMBL13812747 | 0.89 | SMN1; SMN2 (0.52) | NPC1RAB9AMAPTPOLBKDM4E | |
| SCHEMBL13812765 | 0.89 | KCNK3 (0.55) | NPC1RAB9AMAPTPOLBMEN1 | |
| SCHEMBL13812803 | 0.87 | TRPV1 (0.50) | LRRK2NPC1RAB9AMAPTPOLB | |
| SCHEMBL13812938 | 0.87 | GAA (0.47) | NPC1RAB9AMAPTPOLBMEN1 | |
| SCHEMBL13812809 | 0.87 | POLB (0.51) | LRRK2NPC1RAB9AMAPTPOLB | |
| SCHEMBL13812936 | 0.87 | FADS1 (0.49) | NPC1RAB9AMAPTPOLBMEN1 | |
| SCHEMBL13812940 | 0.86 | LRRK2 (0.48) | LRRK2STAT3NPC1RAB9APOLB | |
| SCHEMBL13812934 | 0.86 | KCNK3 (0.47) | NPC1RAB9APOLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7547804-B2 | Compounds, compositions, and methods employing same | MYRIAD GENETICS, INC. (US) | 2009-06-16 | — | — | US | disclosed |
| US-7547804-B2 | Compounds, compositions, and methods employing same | MYRIAD GENETICS, INC. (US) | 2009-06-16 | — | — | US | disclosed |