Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMPRSS4 | Q9NRS4 | 9/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | MRGPRX1 | Q96LB2 | 3/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | KCNMA1 | Q12791 | 2/20 | 0.38 |
| ▸ | DDX3X | O00571 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.36 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.36 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13812838 | 0.85 | TMPRSS4 (0.55) | TMPRSS4GRM5MRGPRX1KCNMA1KDM4E | |
| SCHEMBL13812727 | 0.83 | TMPRSS4 (0.51) | TMPRSS4GRM5MRGPRX1KCNMA1KDM4E | |
| SCHEMBL13812629 | 0.80 | TMPRSS4 (0.55) | TMPRSS4GRM5KCNMA1KDM4EMEN1 | |
| SCHEMBL13812687 | 0.79 | TMPRSS4 (0.50) | TMPRSS4GRM5MRGPRX1KCNMA1KDM4E | |
| SCHEMBL13812695 | 0.78 | KCNMA1 (0.52) | TMPRSS4GRM5MRGPRX1KCNMA1KDM4E | |
| SCHEMBL13812685 | 0.77 | TMPRSS4 (0.65) | TMPRSS4LRRK2KCNMA1KDM4EMEN1 | |
| SCHEMBL13812728 | 0.76 | TMPRSS4 (0.50) | TMPRSS4KCNMA1KDM4EMEN1GAA | |
| SCHEMBL13812682 | 0.76 | TMPRSS4 (0.50) | TMPRSS4GRM5KCNMA1KDM4EMEN1 | |
| SCHEMBL13812730 | 0.74 | TMPRSS4 (0.49) | TMPRSS4KCNMA1MEN1USP2TP53 | |
| SCHEMBL13812729 | 0.74 | TMPRSS4 (0.53) | TMPRSS4GRM5KCNMA1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8796267-B2 | Oxazolidinone derivatives and methods of use | CONCERT PHARMACEUTICALS, INC. (US) | 2014-08-05 | — | — | US | disclosed |
| US-7547804-B2 | Compounds, compositions, and methods employing same | MYRIAD GENETICS, INC. (US) | 2009-06-16 | — | — | US | disclosed |
| US-7547804-B2 | Compounds, compositions, and methods employing same | MYRIAD GENETICS, INC. (US) | 2009-06-16 | — | — | US | disclosed |