Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | KCNK3 | O14649 | 3/20 | 0.45 |
| ▸ | KCNK9 | Q9NPC2 | 3/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13812747 | 0.87 | SMN1; SMN2 (0.52) | NPC1RAB9AKDM4ESMN1; SMN2MAPT | |
| SCHEMBL13812739 | 0.87 | SMN1; SMN2 (0.52) | NPC1RAB9AKDM4ESMN1; SMN2MAPT | |
| SCHEMBL13812950 | 0.85 | RAB9A (0.58) | NPC1RAB9AKDM4ESMN1; SMN2MAPT | |
| SCHEMBL13812765 | 0.84 | KCNK3 (0.55) | NPC1RAB9AKDM4ESMN1; SMN2MAPT | |
| SCHEMBL13812935 | 0.84 | FADS1 (0.47) | NPC1RAB9AKDM4ESMN1; SMN2MAPT | |
| SCHEMBL13812746 | 0.84 | POLB (0.55) | NPC1RAB9ASMN1; SMN2MAPTHPGD | |
| SCHEMBL13812750 | 0.84 | FADS1 (0.58) | NPC1RAB9AKDM4ESMN1; SMN2MAPT | |
| SCHEMBL13812742 | 0.83 | KCNK3 (0.56) | NPC1RAB9AKDM4ESMN1; SMN2MAPT | |
| SCHEMBL13812947 | 0.83 | SIRT2 (0.47) | NPC1RAB9AKDM4ESMN1; SMN2MAPT | |
| SCHEMBL13812776 | 0.83 | KCNK3 (0.51) | NPC1RAB9AKDM4ESMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7547804-B2 | Compounds, compositions, and methods employing same | MYRIAD GENETICS, INC. (US) | 2009-06-16 | — | — | US | disclosed |
| US-7547804-B2 | Compounds, compositions, and methods employing same | MYRIAD GENETICS, INC. (US) | 2009-06-16 | — | — | US | disclosed |