Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.38 |
| ▸ | PLK1 | P53350 | 10/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.35 |
| ▸ | CDC7 | O00311 | 1/20 | 0.35 |
| ▸ | PLK4 | O00444 | 1/20 | 0.35 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | GSK3A | P49840 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | PRKX | P51817 | 1/20 | 0.35 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.35 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.35 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9693871 | 0.72 | ADRA1D (0.45) | ADRA1DADRA1AADRA1BALDH1A1 | |
| SCHEMBL23978923 | 0.72 | ADRA1D (0.45) | ADRA1DADRA1AADRA1BALDH1A1MAOA | |
| SCHEMBL1358972 | 0.70 | CETP (0.54) | ALDH1A1PTPRC | |
| SCHEMBL21799647 | 0.69 | PLK1 (0.41) | PLK1ALDH1A1 | |
| SCHEMBL13813004 | 0.69 | PLK1 (0.41) | ADRA1DADRA1AADRA1BPLK1ALDH1A1 | |
| SCHEMBL8163575 | 0.67 | ALDH1A1 (0.48) | PLK1ALDH1A1 | |
| SCHEMBL13813002 | 0.67 | ALDH1A1 (0.41) | JAK2PLK1CHEK1CDC7PLK4 | |
| SCHEMBL10599951 | 0.66 | KDM4E (0.45) | ADRA1AALDH1A1PTPRC | |
| SCHEMBL2422607 | 0.66 | MEN1 (0.47) | ADRA1DADRA1AADRA1BCHEK1CHEK2 | |
| SCHEMBL13365306 | 0.66 | PLK1 (0.41) | PLK1CHEK1CDC7PLK4DAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090149651-A1 | PROCESSES AND INTERMEDIATES FOR PRODUCING AMINOBENZIMIDAZOLE UREAS | VERTEX PHARMACEUTICALS INCORPORATED | 2009-06-11 | — | — | US | disclosed |
| US-20090149651-A1 | PROCESSES AND INTERMEDIATES FOR PRODUCING AMINOBENZIMIDAZOLE UREAS | VERTEX PHARMACEUTICALS INCORPORATED | 2009-06-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090149651-A1 | PROCESSES AND INTERMEDIATES FOR PRODUCING AMINOBENZIMIDAZOLE UREAS | TOP2B, TOP1, TOP2A | JAK2 4215/4885ADRA1D 4531/4885ADRA1A 4403/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.