Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 2/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.52 |
| ▸ | HMGCR | P04035 | 1/20 | 0.52 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.52 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.37 |
| ▸ | GPR84 | Q9NQS5 | 4/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18595378 | 0.89 | HMGCR (0.48) | CHRM1ADRA1AHMGCRTBXA2RHSPD1 | |
| SCHEMBL13800594 | 0.85 | HMGCR (0.52) | CHRM1ADRA1AHMGCRTBXA2RHSPD1 | |
| SCHEMBL28100112 | 0.78 | HMGCR (0.58) | CHRM1ADRA1AHMGCRTBXA2RTDP1 | |
| SCHEMBL16074696 | 0.75 | LMNA (0.32) | TSHR | |
| SCHEMBL724008 | 0.73 | HMGCR (0.64) | CHRM1ADRA1AHMGCRTBXA2RHSPD1 | |
| SCHEMBL28715378 | 0.73 | HMGCR (0.64) | CHRM1ADRA1AHMGCRTBXA2RTDP1 | |
| SCHEMBL15518117 | 0.72 | CHRM1 (0.44) | CHRM1ADRA1AHMGCRTBXA2RHSPD1 | |
| SCHEMBL7766103 | 0.72 | HMGCR (0.56) | CHRM1ADRA1AHMGCRTBXA2RHSPD1 | |
| SCHEMBL14876931 | 0.72 | CHRM1 (0.44) | CHRM1ADRA1AHMGCRTBXA2RHSPD1 | |
| SCHEMBL1928669 | 0.72 | FDPS (0.33) | TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9585964-B2 | Liver targeted conjugates | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2017-03-07 | — | — | US | disclosed |
| EP-1948600-B1 | LIVER TARGETED CONJUGATES | HARVARD COLLEGE (US) | 2014-04-16 | — | — | EP | disclosed |
| US-20130245101-A1 | Liver Targeted Conjugates | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2013-09-19 | — | — | US | disclosed |
| US-20090162316-A1 | LIVER TARGETED CONJUGATES | HARVARD UNIVERSITY (US) | 2009-06-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130245101-A1 | Liver Targeted Conjugates | LDLR, HMGCR, FABP1 | CHRM1 4573/4885ADRA1A 2567/4885HMGCR 2/4885 |
| US-20090162316-A1 | LIVER TARGETED CONJUGATES | HMGCR, FABP1, SLC10A1 | CHRM1 4543/4885ADRA1A 2724/4885HMGCR 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.