Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 8/20 | 0.69 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.69 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.65 |
| ▸ | RELA | Q04206 | 1/20 | 0.56 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.56 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.56 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.56 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.56 |
| ▸ | TOP2A | P11388 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3780915 | 0.93 | GPBAR1 (0.80) | GPBAR1PRKCDNR1H4 | |
| SCHEMBL15713590 | 0.93 | GPBAR1 (0.80) | GPBAR1PRKCDNR1H4 | |
| SCHEMBL13814599 | 0.90 | GPBAR1 (0.81) | GPBAR1PRKCDNR1H4RELATOP2A | |
| SCHEMBL14086941 | 0.89 | GPBAR1 (0.86) | GPBAR1PRKCDNR1H4 | |
| SCHEMBL14111997 | 0.89 | GPBAR1 (0.86) | GPBAR1PRKCDNR1H4 | |
| SCHEMBL15713707 | 0.87 | GPBAR1 (0.81) | GPBAR1RELAEGLN2EGLN1EGLN3 | |
| SCHEMBL16199332 | 0.85 | GPBAR1 (0.79) | GPBAR1PRKCDNR1H4 | |
| SCHEMBL9891262 | 0.85 | GPBAR1 (0.79) | GPBAR1PRKCDNR1H4 | |
| SCHEMBL15713700 | 0.84 | GPBAR1 (0.70) | GPBAR1RELAEGLN2EGLN1EGLN3 | |
| Methyl Betulinate SCHEMBL13098070 | 0.83 | EGLN2 (0.81) | GPBAR1RELAEGLN2EGLN1EGLN3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150272922-A1 | Compounds for Reducing Glucocorticoids, and Methods of Treatment Thereof | BIONICHE ANIMAL HEALTH USA, INC. | 2015-10-01 | — | — | US | disclosed |
| US-20150272922-A1 | Compounds for Reducing Glucocorticoids, and Methods of Treatment Thereof | BIONICHE ANIMAL HEALTH USA, INC. | 2015-10-01 | — | — | US | disclosed |
| US-20150005267-A1 | ANXIOLYTIC MARCGRAVIACEAE COMPOSITIONS CONTAINING BETULINIC ACID, BETULINIC ACID DERIVATIVES, AND METHODS | UNIV OTTAWA (CA) | 2015-01-01 | — | — | US | disclosed |
| US-20150005267-A1 | ANXIOLYTIC MARCGRAVIACEAE COMPOSITIONS CONTAINING BETULINIC ACID, BETULINIC ACID DERIVATIVES, AND METHODS | UNIV OTTAWA (CA) | 2015-01-01 | — | — | US | disclosed |
| WO-2014071506-A1 | COMPOUNDS FOR REDUCING GLUCOCORTICOIDS, AND METHODS OF TREATMENT THEREOF | BIONICHE LIFE SCIENCES INC. (CA) | 2014-05-15 | — | — | WO | disclosed |
| US-8623848-B2 | Anxiolytic marcgraviaceae compositions containing betulinic acid, betulinic acid derivatives, and methods | UNIVERSITY OF OTTAWA (CA) | 2014-01-07 | — | — | US | disclosed |
| US-8623848-B2 | Anxiolytic marcgraviaceae compositions containing betulinic acid, betulinic acid derivatives, and methods | UNIVERSITY OF OTTAWA (CA) | 2014-01-07 | — | — | US | disclosed |
| US-20130065868-A1 | ANXIOYTIC MARCGRAVIACEAE COMPOSITIONS CONTAINING BETULINIC ACID, BETULINIC ACID DERIVATIVES, AND METHODS | UNIVERSITY OF OTTAWA (CA) | 2013-03-14 | — | — | US | disclosed |
| US-20090143350-A1 | Anxiolytic Marcgraviaceae Compositions Containing Betulinic Acid, Betulinic Acid Derivatives, and Methods | UNIVERSITY OF OTTAWA | 2009-06-04 | — | — | US | disclosed |
| US-20090143350-A1 | Anxiolytic Marcgraviaceae Compositions Containing Betulinic Acid, Betulinic Acid Derivatives, and Methods | UNIVERSITY OF OTTAWA | 2009-06-04 | — | — | US | disclosed |
| US-7488722-B2 | Anxiolytic Marcgraviaceae compositions containing betulinic acid, betulinic acid derivatives, and methods | UNIVERSITY OF OTTAWA (CA) | 2009-02-10 | — | — | US | disclosed |
| US-7488722-B2 | Anxiolytic Marcgraviaceae compositions containing betulinic acid, betulinic acid derivatives, and methods | UNIVERSITY OF OTTAWA (CA) | 2009-02-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090143350-A1 | Anxiolytic Marcgraviaceae Compositions Containing Betulinic Acid, Betulinic Acid Derivatives, and Methods | GABRA5, GABRA6, GABRA1 | GPBAR1 250/4885PRKCD 1557/4885NR1H4 400/4885 |
| US-20150272922-A1 | Compounds for Reducing Glucocorticoids, and Methods of Treatment Thereof | NR3C1, NR5A1, NR3C2 | GPBAR1 230/4885PRKCD 2233/4885NR1H4 410/4885 |
| US-20130065868-A1 | ANXIOYTIC MARCGRAVIACEAE COMPOSITIONS CONTAINING BETULINIC ACID, BETULINIC ACID DERIVATIVES, AND METHODS | GABRA5, GABRA6, GABRA1 | GPBAR1 188/4885PRKCD 1391/4885NR1H4 320/4885 |
| US-20150005267-A1 | ANXIOLYTIC MARCGRAVIACEAE COMPOSITIONS CONTAINING BETULINIC ACID, BETULINIC ACID DERIVATIVES, AND METHODS | GABRA5, GABRA6, GABRA1 | GPBAR1 250/4885PRKCD 1557/4885NR1H4 400/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.