Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 10/20 | 0.68 |
| ▸ | DRD3 | P35462 | 3/20 | 0.56 |
| ▸ | DRD1 | P21728 | 1/20 | 0.56 |
| ▸ | DRD4 | P21917 | 1/20 | 0.56 |
| ▸ | DRD5 | P21918 | 1/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3453568 | 0.84 | DRD2 (0.77) | DRD2DRD3DRD1DRD4DRD5 | |
| SCHEMBL4828691 | 0.81 | DRD2 (0.71) | DRD2DRD3SIGMAR1SLC6A4 | |
| SCHEMBL25316484 | 0.80 | HTT (0.43) | DRD2DRD3DRD1DRD4DRD5 | |
| SCHEMBL4819648 | 0.77 | DRD2 (0.67) | DRD2DRD3DRD1DRD4DRD5 | |
| SCHEMBL10179977 | 0.77 | ENPP3 (0.51) | DRD2DRD3DRD1DRD4DRD5 | |
| SCHEMBL25564212 | 0.76 | DRD2 (0.89) | DRD2DRD3DRD1DRD4DRD5 | |
| SCHEMBL13815499 | 0.76 | DRD2 (0.69) | DRD2DRD3DRD1DRD4DRD5 | |
| SCHEMBL8351025 | 0.76 | DRD2 (0.75) | DRD2SIGMAR1SLC6A4 | |
| SCHEMBL9608741 | 0.76 | ENPP3 (0.54) | DRD2DRD3DRD1DRD4DRD5 | |
| SCHEMBL31223124 | 0.74 | DRD2 (0.73) | DRD2DRD3DRD1DRD4DRD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8314126-B2 | Disubstituted phenylpiperdines/piperazines as modulators of dopamine neurotransmission | NSAB, FILIAL AF NEUROSEARCH SWEDEN AB, SVERIGE (DK) | 2012-11-20 | — | — | US | claimed |