Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 15/20 | 0.68 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.68 |
| ▸ | THRB | P10828 | 1/20 | 0.68 |
| ▸ | PKM | P14618 | 1/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19899574 | 0.84 | MAPT (0.75) | MAPTSIRT6THRBPKMALDH1A1 | |
| SCHEMBL2557640 | 0.84 | LMNA (0.71) | MAPTSIRT6THRBPKMALDH1A1 | |
| SCHEMBL4254979 | 0.83 | SIRT6 (0.65) | MAPTSIRT6THRBPKMALDH1A1 | |
| SCHEMBL21066338 | 0.83 | MAPT (0.73) | MAPTSIRT6THRBPKMALDH1A1 | |
| SCHEMBL12478410 | 0.83 | MAPT (0.73) | MAPTSIRT6THRBPKMALDH1A1 | |
| SCHEMBL8804807 | 0.82 | MAPT (0.47) | MAPTSIRT6THRBPKMALDH1A1 | |
| SCHEMBL31333962 | 0.81 | MAPT (0.59) | MAPTSIRT6THRBPKMALDH1A1 | |
| SCHEMBL311272 | 0.81 | ALDH1A1 (0.73) | MAPTSIRT6THRBPKMALDH1A1 | |
| SCHEMBL13981668 | 0.81 | MAPT (0.69) | MAPTSIRT6THRBPKMALDH1A1 | |
| SCHEMBL14852502 | 0.81 | SIRT6 (1.00) | MAPTSIRT6THRBPKMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090156589-A1 | 1,2-DI(CYCLIC GROUP)SUBSTITUTED BENZENE DERIVATIVE | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2009-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090156589-A1 | 1,2-DI(CYCLIC GROUP)SUBSTITUTED BENZENE DERIVATIVE | CCR10, H1-10, VCAM1 | MAPT 4564/4885SIRT6 4417/4885THRB 1406/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.