Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | APEX1 | P27695 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21654155 | 0.86 | MMP2 (0.51) | GAAHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL11974555 | 0.85 | ALOX15 (0.59) | ALDH1A1LMNAALOX15APEX1MAPK1 | |
| SCHEMBL30503033 | 0.85 | ALOX15 (0.59) | ALDH1A1LMNAALOX15APEX1MAPK1 | |
| SCHEMBL13019728 | 0.83 | SMN1; SMN2 (0.48) | ALDH1A1LMNAALOX15APEX1MAPK1 | |
| SCHEMBL7902328 | 0.83 | ALDH1A1 (0.62) | ALDH1A1LMNAALOX15APEX1MAPK1 | |
| SCHEMBL11775529 | 0.81 | GSK3B (0.65) | ALDH1A1LMNAALOX15APEX1MAPK1 | |
| SCHEMBL19619634 | 0.80 | NPC1 (0.50) | ALDH1A1LMNAALOX15APEX1MAPK1 | |
| SCHEMBL11531068 | 0.79 | ERCC5 (0.58) | ALDH1A1LMNAMMP1NPC1PPARA | |
| SCHEMBL29046810 | 0.79 | ALDH1A1 (0.41) | ALDH1A1LMNAALOX15APEX1MAPK1 | |
| SCHEMBL20076975 | 0.78 | ELANE (0.60) | ALDH1A1LMNAMAPK1TDP1ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7553842-B2 | Macrocyclic analogs for the treatment of immunoregulatory disorders and respiratory diseases | ARRAY BIOPHARMA INC. (US) | 2009-06-30 | — | — | US | disclosed |