Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.44 |
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.44 |
| ▸ | ABAT | P80404 | 1/20 | 0.44 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | FDPS | P14324 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | DRD1 | P21728 | 2/20 | 0.41 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | TTR | P02766 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7842122 | 0.83 | ALDH1A1 (0.50) | ALDH1A1TSHRHPGDTDP1TRIM24 | |
| SCHEMBL10959952 | 0.81 | ALDH1A1 (0.48) | ALDH1A1TSHRHPGDTDP1TRIM24 | |
| SCHEMBL3112001 | 0.80 | ALDH1A1 (0.47) | ALDH1A1TSHRHPGDTDP1TRIM24 | |
| SCHEMBL7832025 | 0.80 | ALDH1A1 (0.47) | ALDH1A1TSHRHPGDTDP1TRIM24 | |
| SCHEMBL16619850 | 0.80 | ALDH1A1 (0.59) | ALDH1A1TSHRHPGDTDP1TRIM24 | |
| SCHEMBL96635 | 0.80 | ALDH1A1 (0.59) | ALDH1A1TSHRHPGDTDP1TRIM24 | |
| SCHEMBL13243772 | 0.79 | ALDH1A1 (0.46) | ALDH1A1TSHRHPGDTDP1TRIM24 | |
| SCHEMBL1966450 | 0.79 | ALDH1A1 (0.70) | ALDH1A1TSHRHPGDTDP1TRIM24 | |
| SCHEMBL140472 | 0.79 | ALDH1A1 (0.70) | ALDH1A1TSHRHPGDTDP1TRIM24 | |
| Hydrochloric Acid SCHEMBL23711567 | 0.78 | ALDH1A1 (0.57) | ALDH1A1TSHRHPGDTDP1TRIM24 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107162928-B | Halogenated analogs of anti-fibrotic agents | 塞尔塔医疗有限公司 | 2022-03-11 | — | — | CN | disclosed |
| EP-3045170-B1 | HALOGENATED ANALOGUES OF ANTI-FIBROTIC AGENTS | FIBROTECH THERAPEUTICS PTY LTD (AU) | 2018-07-04 | — | — | EP | disclosed |
| CN-107162928-A | The halogenated analogues of antifibrotic agents | 法博太科制药有限公司 | 2017-09-15 | — | — | CN | disclosed |
| EP-3045170-A1 | HALOGENATED ANALOGUES OF ANTI-FIBROTIC AGENTS | Fibrotech Therapeutics PTY LTD (AU) | 2016-07-20 | — | — | EP | disclosed |
| EP-3045170-A1 | HALOGENATED ANALOGUES OF ANTI-FIBROTIC AGENTS | Fibrotech Therapeutics PTY LTD (AU) | 2016-07-20 | — | — | EP | disclosed |
| EP-2220028-B1 | HALOGENATED ANALOGUES OF ANTI-FIBROTIC AGENTS | FIBROTECH THERAPEUTICS PTY LTD (AU) | 2016-03-09 | — | — | EP | disclosed |
| EP-2220028-B1 | HALOGENATED ANALOGUES OF ANTI-FIBROTIC AGENTS | FIBROTECH THERAPEUTICS PTY LTD (AU) | 2016-03-09 | — | — | EP | disclosed |
| US-20150336866-A1 | SYNTHESIS OF DIFLUOROMETHYL ETHERS AND SULFIDES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2015-11-26 | — | — | US | disclosed |
| US-20150336866-A1 | SYNTHESIS OF DIFLUOROMETHYL ETHERS AND SULFIDES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2015-11-26 | — | — | US | disclosed |
| US-20150336866-A1 | SYNTHESIS OF DIFLUOROMETHYL ETHERS AND SULFIDES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2015-11-26 | — | — | US | disclosed |
| WO-2014107380-A1 | SYNTHESIS OF DIFLUOROMETHYL ETHERS AND SULFIDES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2014-07-10 | — | — | WO | disclosed |
| WO-2014107380-A1 | SYNTHESIS OF DIFLUOROMETHYL ETHERS AND SULFIDES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2014-07-10 | — | — | WO | disclosed |
| US-8624056-B2 | Halogenated analogues of anti-fibrotic agents | FIBROTECH THERAPEUTICS PTY LTD | 2014-01-07 | — | — | US | disclosed |
| US-8624056-B2 | Halogenated analogues of anti-fibrotic agents | FIBROTECH THERAPEUTICS PTY LTD | 2014-01-07 | — | — | US | disclosed |
| US-20120059188-A9 | HALOGENATED ANALOGUES OF ANTI-FIBROTIC AGENTS | THE UNIVERSITY OF MELBOURNE (AU) | 2012-03-08 | — | — | US | disclosed |
| CN-102164887-A | Halogenated analogs of anti-fibrotic agents | FIBROTECH THERAPEUTICS PTY LTD | 2011-08-24 | — | — | CN | disclosed |
| US-20110021815-A1 | HALOGENATED ANALOGUES OF ANTI-FIBROTIC AGENTS | FIBROTECH THERAPEUTICS PTY LTD (AU) | 2011-01-27 | — | — | US | disclosed |
| EP-2220028-A1 | HALOGENATED ANALOGUES OF ANTI-FIBROTIC AGENTS | Fibrotech Therapeutics PTY LTD (AU) | 2010-08-25 | — | — | EP | disclosed |
| WO-2009079692-A1 | HALOGENATED ANALOGUES OF ANTI-FIBROTIC AGENTS | FIBROTECH THERAPEUTICS PTY LTD (AU) | 2009-07-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150336866-A1 | SYNTHESIS OF DIFLUOROMETHYL ETHERS AND SULFIDES | DDT, ABL1, TYR | ALDH1A1 3454/4885TSHR 784/4885HPGD 3936/4885 |
| US-20120059188-A9 | HALOGENATED ANALOGUES OF ANTI-FIBROTIC AGENTS | MMP1, FIBP, HDGF | ALDH1A1 242/4885TSHR 1427/4885HPGD 1175/4885 |
| US-20110021815-A1 | HALOGENATED ANALOGUES OF ANTI-FIBROTIC AGENTS | MMP1, FIBP, HDGF | ALDH1A1 242/4885TSHR 1427/4885HPGD 1175/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.