Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K7 | O43318 | 6/20 | 0.46 |
| ▸ | TAB1 | Q15750 | 6/20 | 0.46 |
| ▸ | PLAU | P00749 | 1/20 | 0.43 |
| ▸ | CCNC | P24863 | 5/20 | 0.38 |
| ▸ | CDK8 | P49336 | 5/20 | 0.38 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.38 |
| ▸ | PLK4 | O00444 | 3/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.36 |
| ▸ | LCK | P06239 | 3/20 | 0.36 |
| ▸ | FYN | P06241 | 3/20 | 0.36 |
| ▸ | CSF1R | P07333 | 3/20 | 0.36 |
| ▸ | LYN | P07948 | 3/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.36 |
| ▸ | SRC | P12931 | 3/20 | 0.36 |
| ▸ | FLT1 | P17948 | 3/20 | 0.36 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.36 |
| ▸ | FLT4 | P35916 | 3/20 | 0.36 |
| ▸ | KDR | P35968 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4348310 | 0.85 | MAP3K7 (0.44) | MAP3K7TAB1CCNCCDK8PLK4 | |
| SCHEMBL13821697 | 0.80 | MAP3K7 (0.41) | MAP3K7TAB1PLAUCCNCCDK8 | |
| SCHEMBL4352533 | 0.76 | KMT2A (0.57) | MAP3K7TAB1CCNCCDK8CDK19 | |
| SCHEMBL4352528 | 0.76 | KMT2A (0.57) | MAP3K7TAB1CCNCCDK8CDK19 | |
| SCHEMBL29953503 | 0.75 | KMT2A (0.51) | PLAUNTRK1AXLKITDYRK1A | |
| SCHEMBL9906847 | 0.75 | KMT2A (0.51) | PLAUNTRK1AXLKITDYRK1A | |
| SCHEMBL31318227 | 0.73 | MAP4K1 (0.67) | ITKABL1BTK | |
| SCHEMBL13821349 | 0.73 | ALDH1A1 (0.48) | MAP3K7TAB1PLAUGSK3B | |
| SCHEMBL24758308 | 0.72 | TDO2 (0.43) | MAP3K7TAB1PLAUAXL | |
| SCHEMBL16945253 | 0.71 | MAP3K7 (0.42) | MAP3K7TAB1PLK4PRKD3LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2070928-A1 | 7-azaindol-3-ylacrylamides active as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2009-06-17 | — | — | EP | disclosed |