Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K7 | O43318 | 12/20 | 0.44 |
| ▸ | TAB1 | Q15750 | 12/20 | 0.44 |
| ▸ | CCNC | P24863 | 1/20 | 0.36 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.34 |
| ▸ | CLK1 | P49759 | 2/20 | 0.34 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.34 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.34 |
| ▸ | TDO2 | P48775 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.34 |
| ▸ | CDC7 | O00311 | 1/20 | 0.34 |
| ▸ | PLK4 | O00444 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.34 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.34 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13821698 | 0.85 | MAP3K7 (0.46) | MAP3K7TAB1CCNCCDK8DYRK1A | |
| SCHEMBL24197757 | 0.84 | MAP3K7 (0.46) | MAP3K7TAB1CCNCCDK8DYRK1A | |
| SCHEMBL16945239 | 0.83 | MAP3K7 (0.44) | MAP3K7TAB1AXLGSK3B | |
| SCHEMBL18238563 | 0.83 | MAP3K7 (0.44) | MAP3K7TAB1AXLGSK3B | |
| SCHEMBL16945253 | 0.82 | MAP3K7 (0.42) | MAP3K7TAB1MAP3K11DYRK1ACLK1 | |
| SCHEMBL4346955 | 0.80 | MAP3K7 (0.43) | MAP3K7TAB1DYRK1ACLK1DYRK2 | |
| SCHEMBL16932960 | 0.80 | GSK3B (0.56) | MAP3K7TAB1CDK8DYRK1ANTRK1 | |
| SCHEMBL16932959 | 0.80 | GSK3B (0.56) | MAP3K7TAB1CDK8DYRK1ANTRK1 | |
| SCHEMBL16945190 | 0.80 | NEK1 (0.44) | MAP3K7TAB1MAP3K11DYRK1ACLK1 | |
| SCHEMBL4346952 | 0.80 | MAP3K7 (0.43) | MAP3K7TAB1DYRK1ACLK1DYRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2070928-A1 | 7-azaindol-3-ylacrylamides active as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2009-06-17 | — | — | EP | claimed |
| EP-2070928-A1 | 7-azaindol-3-ylacrylamides active as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2009-06-17 | — | — | EP | disclosed |