Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 10/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.39 |
| ▸ | CCR1 | P32246 | 1/20 | 0.39 |
| ▸ | CCR5 | P51681 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.37 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.37 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10287605 | 0.92 | DRD2 (0.41) | DRD2ADRA1ACCR1HTR1ADRD1 | |
| SCHEMBL13617507 | 0.90 | DRD2 (0.42) | DRD2ADRA1ACCR1DRD4OPRM1 | |
| SCHEMBL13824491 | 0.88 | DRD2 (0.38) | DRD2ADRA1ACCR1HTR1ADRD1 | |
| SCHEMBL13824223 | 0.87 | DRD2 (0.38) | DRD2ADRA1ACHRM2CCR1MEN1 | |
| SCHEMBL13824256 | 0.87 | DRD2 (0.37) | DRD2ADRA1ACCR1HTR1ADRD1 | |
| SCHEMBL13824263 | 0.87 | DRD2 (0.39) | DRD2ADRA1AHTR1ADRD1DRD4 | |
| SCHEMBL10288236 | 0.87 | ALDH1A1 (0.41) | DRD2CCR1MEN1HTR1ATSHR | |
| SCHEMBL10287520 | 0.87 | CHRM2 (0.41) | DRD2CHRM2CCR1CCR5DRD4 | |
| SCHEMBL13617080 | 0.86 | DRD2 (0.36) | DRD2CCR1HTR1ADRD1DRD4 | |
| SCHEMBL13616961 | 0.86 | DRD2 (0.36) | DRD2ADRA1ACCR1HTR1ADRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7541365-B2 | Chemokine receptor antagonists and methods of use therefor | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2009-06-02 | — | — | US | disclosed |