Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 6/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CES2 | O00748 | 3/20 | 0.42 |
| ▸ | CES1 | P23141 | 3/20 | 0.42 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | NQO2 | P16083 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13825497 | 1.00 | PDE4A (0.46) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL2284188 | 0.81 | PDE4A (0.46) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL7862071 | 0.81 | PDE4A (0.46) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL2284191 | 0.81 | PDE4A (0.46) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL6937356 | 0.80 | ALDH1A1 (0.65) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| Ammonia Solution, Strong SCHEMBL5700298 | 0.78 | ALDH1A1 (0.63) | PDE4APDE4BPDE4CPDE4DKDM4E | |
| SCHEMBL14376098 | 0.77 | CES2 (0.62) | PDE4APDE4BPDE4CPDE4DCES2 | |
| SCHEMBL8270539 | 0.75 | PDE4A (0.78) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL8270543 | 0.71 | PDE4A (0.77) | PDE4APDE4BPDE4CPDE4DNQO2 | |
| SCHEMBL8247682 | 0.71 | SMN1; SMN2 (0.63) | KDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245019-B1 | 4, 5-DIHYDRO-OXAZOL-2-YL AMINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-11-14 | — | — | EP | disclosed |