Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | GSK3A | P49840 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.36 |
| ▸ | MDM4 | O15151 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6002261 | 0.81 | HCAR2 (0.39) | ALDH1A1LMNAKMT2ASMN1; SMN2CDK2 | |
| SCHEMBL922683 | 0.79 | RAB9A (0.41) | LMNAHSD17B10SMN1; SMN2CDK5RAB9A | |
| SCHEMBL2631599 | 0.78 | ALPL (0.35) | ALDH1A1LMNAKMT2ASMN1; SMN2CDK2 | |
| SCHEMBL14019194 | 0.77 | MAPK1 (0.54) | ALDH1A1LMNAHSD17B10KMT2AGSK3A | |
| SCHEMBL18236188 | 0.76 | SMN1; SMN2 (0.46) | ALDH1A1GSK3BKDM4ESMN1; SMN2CDK5 | |
| SCHEMBL1106976 | 0.76 | CCNA2 (0.40) | ALDH1A1LMNAHSD17B10ADORA1CDK2 | |
| SCHEMBL13827683 | 0.75 | HTT (0.42) | ALDH1A1LMNAHSD17B10ADORA1KDM4E | |
| SCHEMBL18330366 | 0.75 | LMNA (0.53) | ALDH1A1LMNAKMT2AGSK3AGSK3B | |
| SCHEMBL13322188 | 0.74 | LMNA (0.49) | ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL21164625 | 0.74 | SMN1; SMN2 (0.46) | ALDH1A1KMT2AGSK3AGSK3BADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012154880-A1 | PROTEOSTASIS REGULATORS FOR TREATING CYSTIC FIBROSIS AND OTHER PROTEIN MISFOLDING DISEASES | PROTEOSTASIS THERAPEUTICS, INC. (US) | 2012-11-15 | — | — | WO | disclosed |