Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 2/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 7/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 7/20 | 0.33 |
| ▸ | PRKDC | P78527 | 7/20 | 0.33 |
| ▸ | ABL1 | P00519 | 6/20 | 0.33 |
| ▸ | EGFR | P00533 | 6/20 | 0.33 |
| ▸ | HCK | P08631 | 6/20 | 0.33 |
| ▸ | SRC | P12931 | 6/20 | 0.33 |
| ▸ | KDR | P35968 | 6/20 | 0.33 |
| ▸ | MTOR | P42345 | 6/20 | 0.33 |
| ▸ | EPHB4 | P54760 | 6/20 | 0.33 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | PDE2A | O00408 | 4/20 | 0.31 |
| ▸ | BRD4 | O60885 | 2/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | NUDT14 | O95848 | 1/20 | 0.30 |
| ▸ | NUDT5 | Q9UKK9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13828318 | 0.75 | PIK3CD (0.33) | RETPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL130603 | 0.72 | RET (0.56) | RETPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL130631 | 0.61 | PIK3CD (0.49) | RETPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL12647324 | 0.61 | NOTUM (0.51) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL13415398 | 0.59 | NOTUM (0.35) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL23989270 | 0.58 | DDB1 (0.33) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL10260251 | 0.58 | PIK3CD (0.52) | RETPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL1923871 | 0.57 | NOTUM (0.48) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL23580425 | 0.57 | NOTUM (0.51) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL130503 | 0.56 | PIK3CD (0.60) | RETPIK3CDPIK3CAPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9775841-B2 | Compounds as modulators of protein kinases | RHIZEN PHARMACEUTICALS SA (CH) | 2017-10-03 | — | — | US | disclosed |
| US-20120289496-A1 | NOVEL COMPOUNDS AS MODULATORS OF PROTEIN KINASES | RHIZEN PHARMACEUTICALS SA (CH) | 2012-11-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120289496-A1 | NOVEL COMPOUNDS AS MODULATORS OF PROTEIN KINASES | PRKCA, PRKCH, PRKCB | RET 733/4885PIK3CD 47/4885PIK3CA 88/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.