Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP3 | P08254 | 1/20 | 0.38 |
| ▸ | MMP7 | P09237 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1382978 | 0.71 | SMN1; SMN2 (0.53) | GAAALDH1A1SMN1; SMN2MMP1MMP3 | |
| SCHEMBL6189155 | 0.70 | MEN1 (0.50) | MEN1KMT2AGAATSHRALDH1A1 | |
| SCHEMBL1380919 | 0.69 | CYP3A4 (0.45) | MEN1KMT2AALDH1A1CYP2C19CYP3A4 | |
| SCHEMBL6190430 | 0.67 | MEN1 (0.42) | MEN1KMT2AGAATSHRALDH1A1 | |
| SCHEMBL14417973 | 0.64 | ALDH1A1 (0.73) | MEN1KMT2AALDH1A1CYP2C19LMNA | |
| SCHEMBL4035054 | 0.64 | ALDH1A1 (0.39) | MEN1KMT2AGAAALDH1A1CYP2C19 | |
| SCHEMBL17833176 | 0.62 | MMP2 (0.59) | GAAALDH1A1CYP2C19CYP3A4SMN1; SMN2 | |
| SCHEMBL695071 | 0.62 | MMP2 (0.59) | GAAALDH1A1CYP2C19CYP3A4SMN1; SMN2 | |
| SCHEMBL4704780 | 0.62 | ALDH1A1 (0.46) | MEN1KMT2AGAATSHRALDH1A1 | |
| SCHEMBL5105399 | 0.62 | CYP3A4 (0.43) | MEN1KMT2ATSHRALDH1A1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4825664-B2 | — | — | 2011-11-30 | — | — | JP | claimed |
| EP-1592389-A2 | PIPERAZINE-2-CARBOXAMIDE DERIVATIVES | Applied Research Systems ARS Holding N.V. (AN) | 2005-11-09 | — | — | EP | claimed |
| WO-2004071390-A2 | PIPERAZINE-2-CARBOXAMIDE DERIVATIVES | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2004-08-26 | — | — | WO | claimed |
| EP-1592389-A2 | PIPERAZINE-2-CARBOXAMIDE DERIVATIVES | Applied Research Systems ARS Holding N.V. (AN) | 2005-11-09 | — | — | EP | disclosed |
| WO-2004071390-A2 | PIPERAZINE-2-CARBOXAMIDE DERIVATIVES | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2004-08-26 | — | — | WO | disclosed |