Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 4/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1383365 | 0.80 | GAA (0.53) | KMT2ATSHRL3MBTL1MAPTALDH1A1 | |
| SCHEMBL1380919 | 0.73 | CYP3A4 (0.45) | MEN1KMT2ACYP3A4CYP2C19LMNA | |
| SCHEMBL6190430 | 0.71 | MEN1 (0.42) | MEN1KMT2ATSHRCYP3A4CYP2C19 | |
| SCHEMBL1382974 | 0.70 | MEN1 (0.43) | MEN1KMT2ATSHRCYP3A4CYP2C19 | |
| SCHEMBL5105399 | 0.68 | CYP3A4 (0.43) | MEN1KMT2ATSHRCYP3A4CYP2C19 | |
| SCHEMBL13409104 | 0.67 | TSHR (0.73) | MEN1KMT2ATSHRCYP3A4CYP2C19 | |
| SCHEMBL13390982 | 0.66 | TSHR (0.71) | MEN1KMT2ATSHRCYP3A4CYP2C19 | |
| SCHEMBL17833176 | 0.66 | MMP2 (0.59) | CYP3A4CYP2C19LMNAMAPTNPSR1 | |
| SCHEMBL695071 | 0.66 | MMP2 (0.59) | CYP3A4CYP2C19LMNAMAPTNPSR1 | |
| SCHEMBL4704780 | 0.65 | ALDH1A1 (0.46) | MEN1KMT2ATSHRCYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1592389-A2 | PIPERAZINE-2-CARBOXAMIDE DERIVATIVES | Applied Research Systems ARS Holding N.V. (AN) | 2005-11-09 | — | — | EP | disclosed |
| WO-2004071390-A2 | PIPERAZINE-2-CARBOXAMIDE DERIVATIVES | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2004-08-26 | — | — | WO | disclosed |