Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MMP3 | P08254 | 8/20 | 0.43 |
| ▸ | MMP1 | P03956 | 7/20 | 0.43 |
| ▸ | MMP9 | P14780 | 4/20 | 0.43 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.43 |
| ▸ | MMP8 | P22894 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | MMP7 | P09237 | 4/20 | 0.41 |
| ▸ | MMP2 | P08253 | 2/20 | 0.41 |
| ▸ | MMP13 | P45452 | 2/20 | 0.40 |
| ▸ | MMP14 | P50281 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1381205 | 0.82 | ALOX15 (0.43) | LMNAALDH1A1MAPT | |
| SCHEMBL6189155 | 0.73 | MEN1 (0.50) | CYP3A4CYP2C19LMNAMEN1KMT2A | |
| SCHEMBL1381034 | 0.71 | KCNH2 (0.46) | MMP3MMP1MMP9MMP2MMP13 | |
| SCHEMBL6190430 | 0.70 | MEN1 (0.42) | CYP3A4CYP2C19MEN1KMT2AALDH1A1 | |
| SCHEMBL1382974 | 0.69 | MEN1 (0.43) | CYP3A4CYP2C19LMNASMN1; SMN2MEN1 | |
| SCHEMBL1380921 | 0.68 | MMP1 (0.54) | CYP3A4LMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL7369631 | 0.68 | MMP1 (0.56) | LMNASMN1; SMN2ALDH1A1MMP3MMP1 | |
| SCHEMBL4036533 | 0.67 | MMP3 (0.43) | LMNASMN1; SMN2KMT2AALDH1A1MMP3 | |
| SCHEMBL7533195 | 0.65 | ALDH1A1 (0.64) | LMNASMN1; SMN2ALDH1A1MMP3MMP1 | |
| SCHEMBL5105399 | 0.65 | CYP3A4 (0.43) | CYP3A4CYP2C19LMNASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4825664-B2 | — | — | 2011-11-30 | — | — | JP | claimed |
| EP-1592389-A2 | PIPERAZINE-2-CARBOXAMIDE DERIVATIVES | Applied Research Systems ARS Holding N.V. (AN) | 2005-11-09 | — | — | EP | claimed |
| WO-2004071390-A2 | PIPERAZINE-2-CARBOXAMIDE DERIVATIVES | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2004-08-26 | — | — | WO | claimed |