Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 13/20 | 0.81 |
| ▸ | GABRB3 | P28472 | 13/20 | 0.81 |
| ▸ | GABRA5 | P31644 | 13/20 | 0.81 |
| ▸ | GABRA1 | P14867 | 11/20 | 0.81 |
| ▸ | GABRA3 | P34903 | 11/20 | 0.81 |
| ▸ | GABRA2 | P47869 | 11/20 | 0.81 |
| ▸ | GABRA6 | Q16445 | 11/20 | 0.81 |
| ▸ | GABRA4 | P48169 | 4/20 | 0.76 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | GABRP | O00591 | 1/20 | 0.48 |
| ▸ | GABRD | O14764 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | GABRE | P78334 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8238208 | 0.89 | GABRG2 (1.00) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL8238213 | 0.89 | GABRG2 (1.00) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL8235515 | 0.88 | GABRG2 (0.81) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL17088108 | 0.86 | GABRG2 (0.78) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL6847260 | 0.86 | GABRG2 (1.00) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL8238309 | 0.85 | GABRG2 (1.00) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL8235750 | 0.84 | GABRG2 (1.00) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL13835663 | 0.80 | GABRG2 (0.77) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL13353154 | 0.80 | GABRG2 (0.68) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL17088115 | 0.80 | GABRG2 (0.68) | GABRG2GABRB3GABRA5GABRA1GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9597342-B2 | GABAergic receptor subtype selective ligands and their uses | UWM RESEARCH FOUNDATION, INC. (US) | 2017-03-21 | — | — | US | disclosed |
| US-9597342-B2 | GABAergic receptor subtype selective ligands and their uses | UWM RESEARCH FOUNDATION, INC. (US) | 2017-03-21 | — | — | US | disclosed |
| US-9597342-B2 | GABAergic receptor subtype selective ligands and their uses | UWM RESEARCH FOUNDATION, INC. (US) | 2017-03-21 | — | — | US | disclosed |
| US-20150258128-A1 | GABAERGIC RECEPTOR SUBTYPE SELECTIVE LIGANDS AND THEIR USES | UWM RESEARCH FOUNDATION, INC. | 2015-09-17 | — | — | US | disclosed |
| US-20150258128-A1 | GABAERGIC RECEPTOR SUBTYPE SELECTIVE LIGANDS AND THEIR USES | UWM RESEARCH FOUNDATION, INC. | 2015-09-17 | — | — | US | disclosed |
| US-20150258128-A1 | GABAERGIC RECEPTOR SUBTYPE SELECTIVE LIGANDS AND THEIR USES | UWM RESEARCH FOUNDATION, INC. | 2015-09-17 | — | — | US | disclosed |
| US-9006233-B2 | Gabaergic receptor subtype selective ligands and their uses | UWM RESEARCH FOUNDATION, INC. (US) | 2015-04-14 | — | — | US | disclosed |
| US-9006233-B2 | Gabaergic receptor subtype selective ligands and their uses | UWM RESEARCH FOUNDATION, INC. (US) | 2015-04-14 | — | — | US | disclosed |
| US-9006233-B2 | Gabaergic receptor subtype selective ligands and their uses | UWM RESEARCH FOUNDATION, INC. (US) | 2015-04-14 | — | — | US | disclosed |
| US-20120295892-A1 | GABAERGIC RECEPTOR SUBTYPE SELECTIVE LIGANDS AND THEIR USES | UWM RESEARCH FOUNDATION, INC. (US) | 2012-11-22 | — | — | US | disclosed |
| US-20120295892-A1 | GABAERGIC RECEPTOR SUBTYPE SELECTIVE LIGANDS AND THEIR USES | UWM RESEARCH FOUNDATION, INC. (US) | 2012-11-22 | — | — | US | disclosed |
| US-20120295892-A1 | GABAERGIC RECEPTOR SUBTYPE SELECTIVE LIGANDS AND THEIR USES | UWM RESEARCH FOUNDATION, INC. (US) | 2012-11-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150258128-A1 | GABAERGIC RECEPTOR SUBTYPE SELECTIVE LIGANDS AND THEIR USES | GABRA3, GABRA2, GABRB3 | GABRG2 10/4885GABRB3 3/4885GABRA5 13/4885 |
| US-20120295892-A1 | GABAERGIC RECEPTOR SUBTYPE SELECTIVE LIGANDS AND THEIR USES | GABRA3, GABRA2, GABRB3 | GABRG2 10/4885GABRB3 3/4885GABRA5 13/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.