Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHB4 | P54760 | 3/20 | 0.51 |
| ▸ | ABL1 | P00519 | 5/20 | 0.46 |
| ▸ | TEK | Q02763 | 4/20 | 0.46 |
| ▸ | LCK | P06239 | 4/20 | 0.46 |
| ▸ | KDR | P35968 | 3/20 | 0.46 |
| ▸ | KIT | P10721 | 3/20 | 0.46 |
| ▸ | SRC | P12931 | 3/20 | 0.46 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.46 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.46 |
| ▸ | FES | P07332 | 1/20 | 0.46 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.46 |
| ▸ | FLT1 | P17948 | 1/20 | 0.46 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.46 |
| ▸ | EPHA3 | P29320 | 1/20 | 0.46 |
| ▸ | BMX | P51813 | 1/20 | 0.46 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.46 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16194905 | 0.88 | BRAF (0.54) | BRAF | |
| SCHEMBL16195447 | 0.78 | BRPF1 (0.56) | BRD4BRPF1BRAF | |
| SCHEMBL10092868 | 0.76 | CSF1R (0.55) | ABL1LCKKDRKITSRC | |
| SCHEMBL13838142 | 0.74 | RAB9A (0.53) | ABL1LCKKDRKITSRC | |
| SCHEMBL13837913 | 0.73 | CSF1R (0.53) | ABL1LCKKDRKITSRC | |
| SCHEMBL3139779 | 0.72 | TNK2 (0.62) | EPHB4ABL1TEKLCKKDR | |
| SCHEMBL13837919 | 0.72 | NPC1 (0.32) | EPHB4 | |
| SCHEMBL12065276 | 0.70 | LCK (0.55) | ABL1LCKKDRKITSRC | |
| SCHEMBL30338817 | 0.70 | SYK (0.57) | EPHB4ABL1TEKLCKKDR | |
| SCHEMBL3135923 | 0.70 | SYK (0.57) | EPHB4ABL1TEKLCKKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012148792-A1 | HETEROCYCLIC COMPOUNDS AS B-RAF INHIBITORS FOR TREATMENT OF CANCER | MERCK SHARP & DOHME CORP. (US) | 2012-11-01 | — | — | WO | disclosed |