Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | GABRP | O00591 | 1/20 | 0.42 |
| ▸ | GABRD | O14764 | 1/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.42 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.42 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.42 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.42 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.42 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.42 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.42 |
| ▸ | GABRE | P78334 | 1/20 | 0.42 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.42 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.42 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.42 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.42 |
| ▸ | NNMT | P40261 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13727146 | 0.86 | SMN1; SMN2 (0.42) | SMN1; SMN2ALDH1A1GABRPGABRDGABRA1 | |
| SCHEMBL13727145 | 0.86 | SMN1; SMN2 (0.42) | SMN1; SMN2ALDH1A1GABRPGABRDGABRA1 | |
| SCHEMBL244032 | 0.81 | SMN1; SMN2 (0.68) | SMN1; SMN2ALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL13838568 | 0.76 | SMN1; SMN2 (0.47) | SMN1; SMN2ALDH1A1GABRPGABRDGABRA1 | |
| SCHEMBL875642 | 0.74 | MGLL (0.60) | SMN1; SMN2ALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL333949 | 0.73 | — | — | |
| SCHEMBL29715865 | 0.73 | — | — | |
| SCHEMBL18228137 | 0.73 | NNMT (0.58) | SMN1; SMN2ALDH1A1NNMTKDM4EMAPT | |
| SCHEMBL4500005 | 0.71 | LTA4H (0.61) | MAPTKMT2AMAP4K4CHEK2 | |
| SCHEMBL4927587 | 0.69 | NNMT (0.49) | SMN1; SMN2ALDH1A1GABRA5NNMTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012151355-A1 | COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP. (US) | 2012-11-08 | — | — | WO | disclosed |