Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.40 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | HPGDS | O60760 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13843808 | 0.78 | HPGDS (0.50) | KDM4EHSD17B10TLR7ALDH1A1MAPK14 | |
| SCHEMBL16193332 | 0.76 | KDM4E (0.59) | KDM4EHSD17B10ADORA3ADORA2AADORA2B | |
| SCHEMBL28995656 | 0.75 | LMNA (0.31) | TSHRALDH1A1 | |
| SCHEMBL7913638 | 0.75 | KDM4E (0.58) | KDM4EHSD17B10ADORA3ADORA2AADORA2B | |
| SCHEMBL4030659 | 0.71 | KDM4E (0.54) | KDM4EHSD17B10ADORA3ADORA2AADORA2B | |
| SCHEMBL11768659 | 0.68 | KDM4E (0.50) | KDM4EHSD17B10ADORA2AADORA2BALDH1A1 | |
| SCHEMBL761987 | 0.67 | KDM4E (0.49) | KDM4EHSD17B10ADORA3ADORA2AADORA2B | |
| SCHEMBL18419644 | 0.66 | KDM4E (0.47) | KDM4EHSD17B10TLR7TSHRALDH1A1 | |
| SCHEMBL19419968 | 0.66 | KDM4E (0.47) | KDM4EHSD17B10ADORA3ADORA2AADORA2B | |
| SCHEMBL650528 | 0.66 | TSHR (0.65) | KDM4EHSD17B10ADORA3ADORA2AADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7531560-B2 | Anti-cytokine heterocyclic compounds | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2009-05-12 | — | — | US | disclosed |
| US-7531560-B2 | Anti-cytokine heterocyclic compounds | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2009-05-12 | — | — | US | disclosed |