Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 7/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.43 |
| ▸ | CCR3 | P51677 | 4/20 | 0.41 |
| ▸ | CCR1 | P32246 | 3/20 | 0.41 |
| ▸ | CXCR6 | O00574 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | SSTR5 | P35346 | 3/20 | 0.37 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13844668 | 0.85 | LTA4H (0.62) | LTA4HKCNH2 | |
| SCHEMBL12677338 | 0.81 | LTA4H (0.54) | LTA4HKCNH2CCR3CCR1CXCR6 | |
| SCHEMBL1902462 | 0.80 | CXCR6 (0.53) | LTA4HCXCR6MEN1KMT2A | |
| SCHEMBL12222587 | 0.80 | CXCR6 (0.53) | LTA4HCXCR6MEN1KMT2A | |
| SCHEMBL12642596 | 0.78 | SIGMAR1 (0.43) | LTA4HNPC1 | |
| SCHEMBL12244452 | 0.78 | LTA4H (0.73) | LTA4HKCNH2 | |
| SCHEMBL1905665 | 0.74 | LTA4H (0.46) | LTA4HKCNH2CXCR6MEN1KMT2A | |
| SCHEMBL1905658 | 0.74 | LTA4H (0.46) | LTA4HKCNH2CXCR6MEN1KMT2A | |
| SCHEMBL1905662 | 0.74 | LTA4H (0.46) | LTA4HKCNH2CXCR6MEN1KMT2A | |
| SCHEMBL12222541 | 0.72 | KMT2A (0.58) | LTA4HKCNH2CXCR6MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009058347-A1 | ARYL-SUBSTITUTED BRIDGED OR FUSED DIAMINES AS MODULATORS OF LEUKOTRIENE A4 HYDROLASE | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-05-07 | — | — | WO | disclosed |