Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 2/20 | 0.42 |
| ▸ | JAK3 | P52333 | 11/20 | 0.41 |
| ▸ | JAK2 | O60674 | 5/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL46662 | 0.86 | LMNA (0.51) | SYKHTTMAPK1MEN1PKM | |
| SCHEMBL44934 | 0.74 | AAK1 (0.46) | SYKHTTMAPK1AAK1MEN1 | |
| SCHEMBL26742261 | 0.74 | HTT (0.56) | SYKHTTMAPK1MEN1PKM | |
| SCHEMBL11833609 | 0.72 | HTT (0.68) | HTTMAPK1MEN1KMT2A | |
| SCHEMBL8689929 | 0.70 | LMNA (0.69) | SYKHTTMAPK1MEN1PKM | |
| SCHEMBL8693048 | 0.70 | ELANE (0.52) | SYKHTTMAPK1MEN1PKM | |
| SCHEMBL11790155 | 0.69 | KMT2A (0.69) | HTTMAPK1MEN1PKMKMT2A | |
| SCHEMBL7446183 | 0.68 | HTT (0.55) | HTTMAPK1MEN1PKMKMT2A | |
| SCHEMBL10378109 | 0.68 | HTT (0.54) | HTTMAPK1MEN1PKMKMT2A | |
| SCHEMBL11830768 | 0.68 | DHODH (0.56) | HTTMAPK1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009059162-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA ENTERPRISES LIMITED (BS) | 2009-05-07 | — | — | WO | disclosed |