Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | AHR | P35869 | 1/20 | 0.43 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.41 |
| ▸ | SYK | P43405 | 7/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | DHODH | Q02127 | 2/20 | 0.38 |
| ▸ | GMNN | O75496 | 1/20 | 0.38 |
| ▸ | TTR | P02766 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13844939 | 0.86 | SYK (0.42) | MEN1KMT2AKCNH2SYKHTT | |
| SCHEMBL2714471 | 0.74 | LMNA (0.70) | LMNAMAPTRAB9AALDH1A1NPC1 | |
| SCHEMBL44141 | 0.71 | LMNA (0.56) | LMNAMAPTRAB9AALDH1A1NPC1 | |
| SCHEMBL28282946 | 0.70 | LMNA (0.73) | LMNAMAPTRAB9AALDH1A1NPC1 | |
| SCHEMBL29898238 | 0.69 | LMNA (0.71) | LMNAMAPTRAB9AALDH1A1NPC1 | |
| SCHEMBL28949487 | 0.69 | LMNA (0.71) | LMNAMAPTRAB9AALDH1A1NPC1 | |
| SCHEMBL9496511 | 0.69 | LMNA (1.00) | LMNAMAPTRAB9AALDH1A1NPC1 | |
| SCHEMBL28309786 | 0.69 | LMNA (0.71) | LMNAMAPTRAB9AALDH1A1NPC1 | |
| SCHEMBL5083062 | 0.69 | RAB9A (0.72) | LMNAMAPTRAB9AALDH1A1NPC1 | |
| SCHEMBL5255345 | 0.69 | LMNA (0.71) | LMNAMAPTRAB9AALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2214669-B1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA ENTPR LTD (BS) | 2015-04-01 | — | — | EP | disclosed |
| WO-2011137587-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA LIMITED (CN) | 2011-11-10 | — | — | WO | disclosed |
| WO-2009059162-A1 | CYTOKINE INHIBITORS | HUTCHISON MEDIPHARMA ENTERPRISES LIMITED (BS) | 2009-05-07 | — | — | WO | disclosed |