Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | NAAA | Q02083 | 1/20 | 0.47 |
| ▸ | USP5 | P45974 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | RORC | P51449 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14095896 | 0.86 | CYP19A1 (0.44) | MEN1KMT2ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL3295631 | 0.80 | NAAA (0.38) | MEN1KMT2AMAPTSMN1; SMN2NAAA | |
| SCHEMBL14095894 | 0.80 | MAPT (0.63) | MEN1KMT2AMAPTSMN1; SMN2USP5 | |
| SCHEMBL14095854 | 0.77 | KMT2A (0.67) | MEN1KMT2ASMN1; SMN2NPC1RAB9A | |
| SCHEMBL13392256 | 0.74 | LMNA (0.47) | MEN1KMT2AMAPTNPC1RAB9A | |
| SCHEMBL13489653 | 0.73 | SMN1; SMN2 (0.68) | MEN1KMT2AMAPTSMN1; SMN2USP5 | |
| SCHEMBL5898968 | 0.73 | MMP2 (0.63) | NAAANPC1RAB9AEPHX2 | |
| SCHEMBL11511360 | 0.73 | KDM4E (0.76) | MEN1KMT2AMAPTSMN1; SMN2PKM | |
| SCHEMBL854850 | 0.72 | MAPT (0.50) | MEN1KMT2AMAPTSMN1; SMN2TP53 | |
| SCHEMBL29605026 | 0.72 | AVPR1A (0.49) | NAAAEPHX2KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009056693-A1 | NOVEL DERIVATIVES OF N, N'- 2, 4-DIANILINOPYRIMIDINES, PREPARATION THEREOF AS MEDICAMENTS PHARMACEUTICAL COMPOSITIONS AND IN PARTICULAR AS IKK INHIBITORS | SANOFI-AVENTIS (FR) | 2009-05-07 | — | — | WO | disclosed |
| WO-2008099073-A1 | N, N' -2, 4-DIANILINOPYRIMIDINES PREPARATION AND USE THEREOF AS IKK INHIBITORS PREPARATION AND TEH PHARMACUETICAL COMPOSITIONS THEREOF | SANOFI-AVENTIS (FR) | 2008-08-21 | — | — | WO | disclosed |