Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14574452 | 1.00 | DPP4 (0.48) | DPP4LMNACYP2D6SRCPKM | |
| SCHEMBL28949706 | 0.76 | BCAT2 (0.51) | LMNAPKMSMN1; SMN2MAPK1ALDH1A1 | |
| SCHEMBL15781198 | 0.75 | LMNA (0.43) | LMNACYP2D6SRCPKMSMN1; SMN2 | |
| SCHEMBL15768221 | 0.75 | LMNA (0.43) | LMNACYP2D6SRCPKMSMN1; SMN2 | |
| SCHEMBL645517 | 0.74 | LMNA (0.65) | LMNACYP2D6SRCPKMSMN1; SMN2 | |
| SCHEMBL1614122 | 0.73 | DPP4 (0.67) | DPP4LMNACYP2D6SRCMAPK1 | |
| SCHEMBL1614121 | 0.73 | DPP4 (0.67) | DPP4LMNACYP2D6SRCMAPK1 | |
| SCHEMBL27610820 | 0.73 | DPP4 (0.59) | DPP4LMNACYP2D6SRCPKM | |
| SCHEMBL7266296 | 0.71 | CYP2D6 (0.70) | DPP4LMNACYP2D6SRCMAPK1 | |
| SCHEMBL487425 | 0.71 | DPP4 (0.56) | DPP4LMNACYP2D6SRCMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1562927-B1 | THIO-ANALOGUES OF PACLITAXEL AND INTERMEDIATES THEREOF | CHATHAM BIOTEC LTD (CA) | 2009-05-13 | — | — | EP | disclosed |