Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | HTR1B | P28222 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1144675 | 0.96 | SMN1; SMN2 (0.44) | L3MBTL1TDP1KDM4EGAAMAPT | |
| SCHEMBL30519457 | 0.90 | MAPT (0.42) | L3MBTL1TDP1KDM4EGAAMAPT | |
| SCHEMBL1144804 | 0.90 | MAPT (0.42) | L3MBTL1TDP1KDM4EGAAMAPT | |
| SCHEMBL22005040 | 0.89 | KDM4E (0.44) | L3MBTL1TDP1KDM4EGAAMAPT | |
| SCHEMBL22005008 | 0.87 | NPC1 (0.47) | L3MBTL1TDP1KDM4EGAAMAPT | |
| SCHEMBL2705419 | 0.85 | KDM4E (0.44) | L3MBTL1TDP1KDM4EGAAMAPT | |
| SCHEMBL797140 | 0.85 | L3MBTL1 (0.49) | L3MBTL1TDP1KDM4EGAAMAPT | |
| SCHEMBL9598552 | 0.84 | CYP1A2 (0.53) | L3MBTL1TDP1MAPTLMNACYP1A2 | |
| SCHEMBL22005000 | 0.83 | MAPT (0.50) | L3MBTL1TDP1KDM4EGAAMAPT | |
| SCHEMBL4660995 | 0.82 | LMNA (0.54) | L3MBTL1MAPTALDH1A1LMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009064955-A1 | MACROCYCLIC TETRAZOLYL HEPATITIS C SERINE PROTEASE INHIBITORS | ENANTA PHARMACEUTICALS, INC. (US) | 2009-05-22 | — | — | WO | disclosed |