Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.76 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.76 |
| ▸ | HPGD | P15428 | 5/20 | 0.76 |
| ▸ | HTT | P42858 | 4/20 | 0.76 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.76 |
| ▸ | POLB | P06746 | 2/20 | 0.76 |
| ▸ | GAA | P10253 | 2/20 | 0.76 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.76 |
| ▸ | LMNA | P02545 | 4/20 | 0.71 |
| ▸ | CA1 | P00915 | 1/20 | 0.67 |
| ▸ | CA2 | P00918 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 2/20 | 0.65 |
| ▸ | TP53 | P04637 | 1/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | TOP2A | P11388 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12325898 | 0.95 | ALDH1A1 (0.68) | ALDH1A1KDM4EHPGDHTTSMN1; SMN2 | |
| SCHEMBL6305080 | 0.89 | ALDH1A1 (0.76) | ALDH1A1KDM4EHPGDHTTSMN1; SMN2 | |
| SCHEMBL4718919 | 0.88 | ALDH1A1 (0.77) | ALDH1A1KDM4EHPGDHTTSMN1; SMN2 | |
| SCHEMBL9162886 | 0.88 | ALDH1A1 (0.76) | ALDH1A1KDM4EHPGDHTTSMN1; SMN2 | |
| SCHEMBL4717454 | 0.87 | ALDH1A1 (0.73) | ALDH1A1KDM4EHPGDHTTSMN1; SMN2 | |
| SCHEMBL6720867 | 0.86 | KDM4E (1.00) | ALDH1A1KDM4EHPGDHTTSMN1; SMN2 | |
| SCHEMBL9407643 | 0.85 | KDM4E (0.60) | ALDH1A1KDM4EHPGDHTTSMN1; SMN2 | |
| SCHEMBL4717706 | 0.85 | ALDH1A1 (0.73) | ALDH1A1KDM4EHPGDHTTSMN1; SMN2 | |
| SCHEMBL4718628 | 0.84 | ALDH1A1 (0.74) | ALDH1A1KDM4EHPGDHTTSMN1; SMN2 | |
| Ciprofloxacin SCHEMBL5929240 | 0.83 | KDM4E (0.75) | ALDH1A1KDM4EHPGDHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8436031-B2 | Transcription factor modulating compounds and methods of use thereof | PARATEK PHARMACEUTICALS, INC. (US) | 2013-05-07 | — | — | US | disclosed |
| US-20090131401-A1 | Transcription factor modulating compounds and methods of use thereof | PARATEK PHARMACEUTICALS, INC. (US) | 2009-05-21 | — | — | US | disclosed |
| US-20090131401-A1 | Transcription factor modulating compounds and methods of use thereof | PARATEK PHARMACEUTICALS, INC. (US) | 2009-05-21 | — | — | US | disclosed |
| US-7405235-B2 | Transcription factor modulating compounds and methods of use thereof | PARATEK PHARMACEUTICALS, INC. (US) | 2008-07-29 | — | — | US | disclosed |
| US-7405235-B2 | Transcription factor modulating compounds and methods of use thereof | PARATEK PHARMACEUTICALS, INC. (US) | 2008-07-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090131401-A1 | Transcription factor modulating compounds and methods of use thereof | JUN, CREBBP, TFEB | ALDH1A1 3948/4885KDM4E 360/4885HPGD 2406/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.