Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 1.00 |
| ▸ | HPGD | P15428 | 6/20 | 1.00 |
| ▸ | HTT | P42858 | 6/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 1.00 |
| ▸ | POLB | P06746 | 2/20 | 1.00 |
| ▸ | GAA | P10253 | 2/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 1.00 |
| ▸ | LMNA | P02545 | 4/20 | 0.85 |
| ▸ | MAPT | P10636 | 2/20 | 0.85 |
| ▸ | TP53 | P04637 | 1/20 | 0.85 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.66 |
| ▸ | MEN1 | O00255 | 4/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.66 |
| ▸ | TSHR | P16473 | 2/20 | 0.66 |
| ▸ | USP2 | O75604 | 1/20 | 0.66 |
| ▸ | NPC1 | O15118 | 1/20 | 0.66 |
| ▸ | DRD3 | P35462 | 1/20 | 0.63 |
| ▸ | ATM | Q13315 | 1/20 | 0.63 |
| ▸ | BRD4 | O60885 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12325899 | 0.95 | KDM4E (0.91) | KDM4EALDH1A1HPGDHTTTDP1 | |
| SCHEMBL9407621 | 0.88 | ALDH1A1 (0.84) | KDM4EALDH1A1HPGDHTTTDP1 | |
| SCHEMBL6308402 | 0.87 | ALDH1A1 (0.81) | KDM4EALDH1A1HPGDHTTTDP1 | |
| SCHEMBL13856427 | 0.86 | ALDH1A1 (0.76) | KDM4EALDH1A1HPGDHTTTDP1 | |
| SCHEMBL4719318 | 0.86 | ALDH1A1 (0.80) | KDM4EALDH1A1HPGDHTTTDP1 | |
| SCHEMBL9223089 | 0.85 | KDM4E (0.74) | KDM4EALDH1A1HPGDHTTTDP1 | |
| SCHEMBL6298452 | 0.82 | ALDH1A1 (0.80) | KDM4EALDH1A1HPGDHTTTDP1 | |
| SCHEMBL8706968 | 0.82 | KDM4E (0.69) | KDM4EALDH1A1HPGDHTTTDP1 | |
| SCHEMBL12325898 | 0.81 | ALDH1A1 (0.68) | KDM4EALDH1A1HPGDHTTTDP1 | |
| Pefloxacin SCHEMBL29594648 | 0.80 | KDM4E (1.00) | KDM4EALDH1A1HPGDHTTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8436031-B2 | Transcription factor modulating compounds and methods of use thereof | PARATEK PHARMACEUTICALS, INC. (US) | 2013-05-07 | — | — | US | disclosed |
| US-8183236-B2 | Compounds with HIV-1 integrase inhibitory activity and use thereof as anti-HIV/AIDS therapeutics | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2012-05-22 | — | — | US | disclosed |
| US-8183236-B2 | Compounds with HIV-1 integrase inhibitory activity and use thereof as anti-HIV/AIDS therapeutics | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2012-05-22 | — | — | US | disclosed |
| US-7928113-B2 | Integrin-binding small molecules | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2011-04-19 | — | — | US | disclosed |
| US-7928113-B2 | Integrin-binding small molecules | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2011-04-19 | — | — | US | disclosed |
| EP-2298308-A2 | Integrin-binding small molecules | University Of Southern California (US) | 2011-03-23 | — | — | EP | disclosed |
| US-20090131401-A1 | Transcription factor modulating compounds and methods of use thereof | PARATEK PHARMACEUTICALS, INC. (US) | 2009-05-21 | — | — | US | disclosed |
| US-20090131401-A1 | Transcription factor modulating compounds and methods of use thereof | PARATEK PHARMACEUTICALS, INC. (US) | 2009-05-21 | — | — | US | disclosed |
| US-20090088420-A1 | COMPOUNDS WITH HIV-1 INTEGRASE INHIBITORY ACTIVITY AND USE THEREOF AS ANTI-HIV/AIDS THERAPEUTICS | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2009-04-02 | — | — | US | disclosed |
| US-20090088420-A1 | COMPOUNDS WITH HIV-1 INTEGRASE INHIBITORY ACTIVITY AND USE THEREOF AS ANTI-HIV/AIDS THERAPEUTICS | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2009-04-02 | — | — | US | disclosed |
| US-7405235-B2 | Transcription factor modulating compounds and methods of use thereof | PARATEK PHARMACEUTICALS, INC. (US) | 2008-07-29 | — | — | US | disclosed |
| US-7405235-B2 | Transcription factor modulating compounds and methods of use thereof | PARATEK PHARMACEUTICALS, INC. (US) | 2008-07-29 | — | — | US | disclosed |
| US-20070155750-A1 | INTEGRIN-BINDING SMALL MOLECULES | USC STEVENS-UNIVERSITY OF SOUTHERN CALIFORNIA | 2007-07-05 | — | — | US | disclosed |
| US-20070155750-A1 | INTEGRIN-BINDING SMALL MOLECULES | USC STEVENS-UNIVERSITY OF SOUTHERN CALIFORNIA | 2007-07-05 | — | — | US | disclosed |
| WO-2007059195-A1 | INTEGRIN-BINDING SMALL MOLECULES | UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2007-05-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090131401-A1 | Transcription factor modulating compounds and methods of use thereof | JUN, CREBBP, TFEB | KDM4E 360/4885ALDH1A1 3948/4885HPGD 2406/4885 |
| US-20070155750-A1 | INTEGRIN-BINDING SMALL MOLECULES | ITGB3, ITGB5, ITGA2B | KDM4E 3949/4885ALDH1A1 2723/4885HPGD 3564/4885 |
| US-20090088420-A1 | COMPOUNDS WITH HIV-1 INTEGRASE INHIBITORY ACTIVITY AND USE THEREOF AS ANTI-HIV/AIDS THERAPEUTICS | TYMP, IMPDH1, SAMHD1 | KDM4E 1795/4885ALDH1A1 265/4885HPGD 1168/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.