Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.69 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.69 |
| ▸ | PTPN22 | Q9Y2R2 | 3/20 | 0.62 |
| ▸ | MEN1 | O00255 | 12/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 12/20 | 0.61 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.60 |
| ▸ | POLB | P06746 | 3/20 | 0.57 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.57 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.57 |
| ▸ | DUSP3 | P51452 | 3/20 | 0.56 |
| ▸ | PTPN7 | P35236 | 2/20 | 0.56 |
| ▸ | DUSP6 | Q16828 | 1/20 | 0.56 |
| ▸ | BLM | P54132 | 3/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13856450 | 0.93 | ALDH1A1 (0.70) | ALDH1A1NPSR1PTPN22MEN1KMT2A | |
| SCHEMBL13856630 | 0.93 | MEN1 (0.65) | ALDH1A1NPSR1PTPN22MEN1KMT2A | |
| SCHEMBL13856568 | 0.92 | ALDH1A1 (0.68) | ALDH1A1NPSR1PTPN22MEN1KMT2A | |
| SCHEMBL13856583 | 0.91 | MEN1 (0.74) | ALDH1A1NPSR1PTPN22MEN1KMT2A | |
| SCHEMBL13856565 | 0.90 | ALDH1A1 (0.66) | ALDH1A1NPSR1PTPN22MEN1KMT2A | |
| SCHEMBL13856552 | 0.89 | PTPN22 (0.69) | ALDH1A1NPSR1PTPN22MEN1KMT2A | |
| SCHEMBL13856661 | 0.88 | PTPN22 (0.75) | ALDH1A1NPSR1PTPN22MEN1KMT2A | |
| SCHEMBL13856789 | 0.88 | CDC25B (0.67) | ALDH1A1NPSR1PTPN22MEN1KMT2A | |
| SCHEMBL13856539 | 0.88 | PTPN22 (0.70) | ALDH1A1NPSR1PTPN22MEN1KMT2A | |
| SCHEMBL14104065 | 0.87 | ALDH1A1 (0.70) | ALDH1A1NPSR1PTPN22MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8436031-B2 | Transcription factor modulating compounds and methods of use thereof | PARATEK PHARMACEUTICALS, INC. (US) | 2013-05-07 | — | — | US | disclosed |
| US-20090131401-A1 | Transcription factor modulating compounds and methods of use thereof | PARATEK PHARMACEUTICALS, INC. (US) | 2009-05-21 | — | — | US | disclosed |
| US-7405235-B2 | Transcription factor modulating compounds and methods of use thereof | PARATEK PHARMACEUTICALS, INC. (US) | 2008-07-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090131401-A1 | Transcription factor modulating compounds and methods of use thereof | JUN, CREBBP, TFEB | ALDH1A1 3948/4885NPSR1 4100/4885PTPN22 4669/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.