Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN22 | Q9Y2R2 | 6/20 | 0.69 |
| ▸ | DUSP3 | P51452 | 4/20 | 0.69 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.69 |
| ▸ | PPM1A | P35813 | 1/20 | 0.69 |
| ▸ | PTPN9 | P43378 | 1/20 | 0.69 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.69 |
| ▸ | PTPN18 | Q99952 | 1/20 | 0.69 |
| ▸ | MEN1 | O00255 | 9/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.64 |
| ▸ | PTPN12 | Q05209 | 2/20 | 0.58 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 3/20 | 0.54 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.53 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.53 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | PTPN7 | P35236 | 3/20 | 0.52 |
| ▸ | DUSP6 | Q16828 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14104225 | 0.94 | PTPN22 (0.70) | PTPN22DUSP3PTPN1PPM1APTPN9 | |
| SCHEMBL13856583 | 0.93 | MEN1 (0.74) | PTPN22DUSP3PTPN1PPM1APTPN9 | |
| SCHEMBL13856630 | 0.92 | MEN1 (0.65) | PTPN22DUSP3PTPN1PPM1APTPN9 | |
| SCHEMBL13856484 | 0.89 | ALDH1A1 (0.69) | PTPN22DUSP3PTPN1PPM1APTPN9 | |
| SCHEMBL13856628 | 0.89 | PTPN22 (0.66) | PTPN22DUSP3PTPN1PPM1APTPN9 | |
| SCHEMBL13856506 | 0.89 | PTPN22 (0.66) | PTPN22DUSP3PTPN1PPM1APTPN9 | |
| SCHEMBL13856789 | 0.87 | CDC25B (0.67) | PTPN22DUSP3PTPN1PPM1APTPN9 | |
| SCHEMBL13856618 | 0.85 | MEN1 (0.73) | PTPN22DUSP3PTPN1PPM1APTPN9 | |
| SCHEMBL13856602 | 0.85 | PTPN22 (0.69) | PTPN22DUSP3PTPN1PPM1APTPN9 | |
| SCHEMBL13856659 | 0.84 | PTPN22 (0.69) | PTPN22DUSP3PTPN1PPM1APTPN9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8436031-B2 | Transcription factor modulating compounds and methods of use thereof | PARATEK PHARMACEUTICALS, INC. (US) | 2013-05-07 | — | — | US | disclosed |
| US-20090131401-A1 | Transcription factor modulating compounds and methods of use thereof | PARATEK PHARMACEUTICALS, INC. (US) | 2009-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090131401-A1 | Transcription factor modulating compounds and methods of use thereof | JUN, CREBBP, TFEB | PTPN22 4669/4885DUSP3 2523/4885PTPN1 4764/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.