Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 1.00 |
| ▸ | ALPG | P10696 | 7/20 | 1.00 |
| ▸ | LMNA | P02545 | 6/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 1.00 |
| ▸ | GAA | P10253 | 5/20 | 1.00 |
| ▸ | HPGD | P15428 | 4/20 | 1.00 |
| ▸ | POLB | P06746 | 4/20 | 1.00 |
| ▸ | HTT | P42858 | 4/20 | 1.00 |
| ▸ | ALPL | P05186 | 3/20 | 1.00 |
| ▸ | RECQL | P46063 | 3/20 | 1.00 |
| ▸ | APEX1 | P27695 | 3/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.75 |
| ▸ | TSHR | P16473 | 3/20 | 0.75 |
| ▸ | USP2 | O75604 | 1/20 | 0.75 |
| ▸ | GCGR | P47871 | 1/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.57 |
| ▸ | ALOX12 | P18054 | 3/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3466913 | 0.82 | ALPG (1.00) | MAPTKDM4EALPGLMNASMN1; SMN2 | |
| SCHEMBL26320568 | 0.75 | ALPL (0.80) | MAPTKDM4EALPGLMNASMN1; SMN2 | |
| SCHEMBL15430002 | 0.69 | POLB (0.62) | MAPTKDM4EALPGLMNASMN1; SMN2 | |
| Bromide SCHEMBL3871016 | 0.68 | ALPL (0.68) | MAPTALPGLMNAGAAHPGD | |
| SCHEMBL4205122 | 0.68 | ALDH1A1 (0.67) | MAPTKDM4EALPGLMNASMN1; SMN2 | |
| SCHEMBL16210999 | 0.64 | MAPT (0.69) | MAPTKDM4EALPGSMN1; SMN2GAA | |
| SCHEMBL15429998 | 0.64 | MEN1 (0.72) | MAPTKDM4EALPGLMNASMN1; SMN2 | |
| SCHEMBL13461102 | 0.64 | POLB (0.83) | MAPTALPGSMN1; SMN2HPGDPOLB | |
| SCHEMBL23196643 | 0.63 | ALPG (0.61) | MAPTKDM4EALPGLMNASMN1; SMN2 | |
| SCHEMBL13629728 | 0.63 | MAPT (1.00) | MAPTALPGSMN1; SMN2HPGDPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090118135-A1 | METHODS AND COMPOUNDS FOR REGULATING APOPTOSIS | THE BURNHAM INSTITUTE (US) | 2009-05-07 | — | — | US | disclosed |
| US-20090118135-A1 | METHODS AND COMPOUNDS FOR REGULATING APOPTOSIS | THE BURNHAM INSTITUTE (US) | 2009-05-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090118135-A1 | METHODS AND COMPOUNDS FOR REGULATING APOPTOSIS | BCL2, BAX, BAD | MAPT 3866/4885KDM4E 3373/4885ALPG 353/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.