Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALPL | P05186 | 1/20 | 0.68 |
| ▸ | ALPG | P10696 | 1/20 | 0.68 |
| ▸ | GCGR | P47871 | 1/20 | 0.68 |
| ▸ | MAPT | P10636 | 5/20 | 0.65 |
| ▸ | POLB | P06746 | 3/20 | 0.64 |
| ▸ | APEX1 | P27695 | 1/20 | 0.64 |
| ▸ | RECQL | P46063 | 1/20 | 0.64 |
| ▸ | GAA | P10253 | 2/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 4/20 | 0.57 |
| ▸ | RAB9A | P51151 | 4/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26320568 | 0.83 | ALPL (0.80) | ALPLALPGGCGRMAPTPOLB | |
| SCHEMBL3466913 | 0.81 | ALPG (1.00) | ALPLALPGGCGRMAPTPOLB | |
| SCHEMBL13629728 | 0.79 | MAPT (1.00) | ALPLALPGGCGRMAPTPOLB | |
| SCHEMBL1286369 | 0.78 | POLB (0.79) | ALPLALPGGCGRMAPTPOLB | |
| Benzene SCHEMBL28322799 | 0.78 | POLB (0.79) | ALPLALPGGCGRMAPTPOLB | |
| SCHEMBL13461102 | 0.77 | POLB (0.83) | ALPLALPGGCGRMAPTPOLB | |
| SCHEMBL2261407 | 0.76 | POLB (0.77) | ALPLALPGGCGRMAPTPOLB | |
| SCHEMBL5401249 | 0.76 | POLB (0.77) | ALPLALPGGCGRMAPTPOLB | |
| SCHEMBL9220907 | 0.76 | ALDH1A1 (0.70) | MAPTPOLBAPEX1RECQLALOX5 | |
| SCHEMBL10759434 | 0.76 | ALDH1A1 (0.74) | MAPTPOLBAPEX1RECQLALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7601846-B2 | Compounds having activity as inhibitors of apoptosis | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2009-10-13 | — | — | US | disclosed |
| US-20060122178-A1 | Compounds having activity as inhibitors of apoptosis | REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE | 2006-06-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060122178-A1 | Compounds having activity as inhibitors of apoptosis | BAD, CASP3, BAX | ALPL 2094/4885ALPG 723/4885GCGR 4383/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.