Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMD14 | O00487 | 4/20 | 0.45 |
| ▸ | COPS5 | Q92905 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.38 |
| ▸ | MMP2 | P08253 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | GMNN | O75496 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
| ▸ | CCR1 | P32246 | 1/20 | 0.38 |
| ▸ | THPO | P40225 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL544974 | 0.77 | KDM4E (0.40) | PSMD14COPS5KDM4ELMNAHSP90AA1 | |
| SCHEMBL31167172 | 0.75 | LIMK1 (0.43) | KDM4ELMNAHSP90AA1MMP2TSHR | |
| SCHEMBL358917 | 0.75 | L3MBTL1 (0.43) | PSMD14COPS5KDM4ELMNAHSP90AA1 | |
| SCHEMBL3970053 | 0.75 | HSP90AA1 (0.40) | KDM4ELMNAHSP90AA1MMP2TSHR | |
| SCHEMBL5183987 | 0.75 | LIMK1 (0.43) | KDM4ELMNAHSP90AA1MMP2TSHR | |
| SCHEMBL5182523 | 0.75 | LMNA (0.39) | PSMD14COPS5KDM4ELMNAHSP90AA1 | |
| SCHEMBL9541333 | 0.75 | METAP2 (0.45) | KDM4ELMNAHSP90AA1MMP2TSHR | |
| SCHEMBL8114833 | 0.75 | KDM4E (0.40) | PSMD14COPS5KDM4ELMNAHSP90AA1 | |
| SCHEMBL22430423 | 0.71 | HSP90AA1 (0.35) | KDM4ELMNAHSP90AA1MMP2TSHR | |
| SCHEMBL31297691 | 0.71 | CYP17A1 (0.41) | KDM4ELMNAHSP90AA1MMP2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140235548-A1 | COMPOSITIONS AND METHODS FOR JAMM PROTEIN INHIBITION | CLEAVE BIOSCIENCES, INC. (US) | 2014-08-21 | — | — | US | claimed |
| EP-2710119-A1 | COMPOSITIONS AND METHODS FOR JAMM PROTEIN INHIBITION | Cleave Biosciences, Inc. (US) | 2014-03-26 | — | — | EP | claimed |
| WO-2012158435-A1 | COMPOSITIONS AND METHODS FOR JAMM PROTEIN INHIBITION | ZHOU HAN-JIE (US) | 2012-11-22 | — | — | WO | claimed |
| CN-112645968-B | Fused ring compound containing two boron atoms and two oxygen family atoms and organic electroluminescent device | 中国科学院长春应用化学研究所 | 2022-06-07 | — | — | CN | disclosed |
| CN-112645968-A | Fused ring compound containing two boron atoms and two oxygen family atoms and organic electroluminescent device | 中国科学院长春应用化学研究所 | 2021-04-13 | — | — | CN | disclosed |
| US-20140235548-A1 | COMPOSITIONS AND METHODS FOR JAMM PROTEIN INHIBITION | CLEAVE BIOSCIENCES, INC. (US) | 2014-08-21 | — | — | US | disclosed |
| EP-2710119-A1 | COMPOSITIONS AND METHODS FOR JAMM PROTEIN INHIBITION | Cleave Biosciences, Inc. (US) | 2014-03-26 | — | — | EP | disclosed |
| WO-2012158435-A1 | COMPOSITIONS AND METHODS FOR JAMM PROTEIN INHIBITION | ZHOU HAN-JIE (US) | 2012-11-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140235548-A1 | COMPOSITIONS AND METHODS FOR JAMM PROTEIN INHIBITION | USP24, USP36, USP39 | PSMD14 7/4885COPS5 39/4885KDM4E 2753/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.