Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.35 |
| ▸ | HTR2C | P28335 | 4/20 | 0.35 |
| ▸ | HTR2B | P41595 | 4/20 | 0.35 |
| ▸ | PDE2A | O00408 | 2/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | TDP2 | O95551 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 3/20 | 0.32 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10235172 | 0.81 | PDE2A (0.37) | HTR2AHTR2CHTR2BPDE2AHDAC3 | |
| SCHEMBL2895515 | 0.76 | OPRM1 (0.42) | HTR2CPDE2ACHRNB2CHRNA4CHRNB4 | |
| SCHEMBL3468969 | 0.76 | OPRM1 (0.42) | HTR2CPDE2ACHRNB2CHRNA4CHRNB4 | |
| SCHEMBL3468930 | 0.76 | OPRM1 (0.42) | HTR2CPDE2ACHRNB2CHRNA4CHRNB4 | |
| SCHEMBL13823320 | 0.73 | HTR2C (0.39) | HTR2AHTR2CHTR2BBACE1SLC6A4 | |
| SCHEMBL9231710 | 0.73 | HDAC3 (0.41) | PDE2AHDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL13823155 | 0.72 | PGR (0.32) | — | |
| SCHEMBL10107293 | 0.69 | TDP2 (0.40) | PDE2AHDAC3HDAC1HDAC2HDAC6 | |
| SCHEMBL2271110 | 0.67 | HDAC3 (0.40) | HTR2AHTR2CHTR2BPDE2AHDAC3 | |
| SCHEMBL11914466 | 0.67 | KCNH2 (0.46) | CHRNB2CHRNA4CHRNB4CHRNA3SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2060570-A2 | Azabicyclo(3.1.0) hexane derivatives useful as modulators of dopamine D3 receptors | Glaxo Group Limited (GB) | 2009-05-20 | — | — | EP | disclosed |