Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lovastatin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR known ✓ | P04035 | 5/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 7/20 | 1.00 |
| ▸ | LMNA | P02545 | 5/20 | 1.00 |
| ▸ | TSHR | P16473 | 5/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 4/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 1.00 |
| ▸ | ALOX15 | P16050 | 3/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 3/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 1.00 |
| ▸ | ITGB2 | P05107 | 2/20 | 1.00 |
| ▸ | ICAM1 | P05362 | 2/20 | 1.00 |
| ▸ | PGR | P06401 | 2/20 | 1.00 |
| ▸ | ABCB1 | P08183 | 2/20 | 1.00 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 1.00 |
| ▸ | MAPT | P10636 | 2/20 | 1.00 |
| ▸ | ADRB3 | P13945 | 2/20 | 1.00 |
| ▸ | ITGAL | P20701 | 2/20 | 1.00 |
| ▸ | TACR2 | P21452 | 2/20 | 1.00 |
| ▸ | TBXA2R | P21731 | 2/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 2/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lovastatin SCHEMBL5063297 | 1.00 | CYP3A4 (1.00) | CYP3A4HMGCRLMNATSHRHIF1A | |
| Lovastatin SCHEMBL16750775 | 1.00 | CYP3A4 (1.00) | CYP3A4HMGCRLMNATSHRHIF1A | |
| Lovastatin SCHEMBL21340570 | 1.00 | CYP3A4 (1.00) | CYP3A4HMGCRLMNATSHRHIF1A | |
| Lovastatin SCHEMBL23468171 | 1.00 | CYP3A4 (1.00) | CYP3A4HMGCRLMNATSHRHIF1A | |
| Lovastatin SCHEMBL8291088 | 1.00 | CYP3A4 (1.00) | CYP3A4HMGCRLMNATSHRHIF1A | |
| Lovastatin SCHEMBL23636214 | 1.00 | CYP3A4 (1.00) | CYP3A4HMGCRLMNATSHRHIF1A | |
| Lovastatin SCHEMBL21340553 | 1.00 | CYP3A4 (1.00) | CYP3A4HMGCRLMNATSHRHIF1A | |
| Lovastatin SCHEMBL21340569 | 1.00 | CYP3A4 (1.00) | CYP3A4HMGCRLMNATSHRHIF1A | |
| Lovastatin SCHEMBL21340572 | 1.00 | CYP3A4 (1.00) | CYP3A4HMGCRLMNATSHRHIF1A | |
| Lovastatin SCHEMBL2894668 | 1.00 | CYP3A4 (1.00) | CYP3A4HMGCRLMNATSHRHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11116739-B2 | Fixed dose combinations and formulations comprising ETC1002 and one or more statins and methods of treating or reducing cardiovascular disease | GLAS AMERICAS LLC | 2021-09-14 | — | — | US | disclosed |
| US-11026942-B2 | Agent for preventing and/or treating Alzheimer's disease | KYOTO UNIVERSITY (JP) | 2021-06-08 | — | — | US | disclosed |
| US-20180078518-A1 | Fixed Dose Combinations and Formulations Comprising ETC1002 and One or More Statins and Methods of Treating or Reducing Cardiovascular Disease | GLAS AMERICAS LLC | 2018-03-22 | — | — | US | disclosed |
| WO-2017133517-A1 | PHOSPHAMIDE DERIVATIVE, METHOD FOR MANUFACTURING THE SAME, AND USES THEREOF | 四川海思科制药有限公司 | 2017-08-10 | — | — | WO | disclosed |
| US-7528265-B2 | Process for the preparation of simvastatin | HANMI PHARM., CO., LTD. (KR) | 2009-05-05 | — | — | US | disclosed |
| US-7528265-B2 | Process for the preparation of simvastatin | HANMI PHARM., CO., LTD. (KR) | 2009-05-05 | — | — | US | disclosed |
| US-RE40667-E1 | [R-(R*R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid, its lactone form and salts thereof | WARNER-LAMBERT COMPANY LLC (US) | 2009-03-17 | — | — | US | disclosed |
| US-20090043115-A1 | Process for Producing Simvastatin | PFICKER PHARMACEUTICALS LTD. (CN) | 2009-02-12 | — | — | US | disclosed |
| US-20090043115-A1 | Process for Producing Simvastatin | PFICKER PHARMACEUTICALS LTD. (CN) | 2009-02-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11026942-B2 | Agent for preventing and/or treating Alzheimer's disease | PSEN1, NOS1, ACHE | HMGCR 70/4885CYP3A4 784/4885LMNA 1393/4885 |
| US-20180078518-A1 | Fixed Dose Combinations and Formulations Comprising ETC1002 and One or More Statins and Methods of Treating or Reducing Cardiovascular Disease | APOB, GOT2, HDLBP | HMGCR 5/4885CYP3A4 1407/4885LMNA 1918/4885 |
| US-11116739-B2 | Fixed dose combinations and formulations comprising ETC1002 and one or more statins and methods of treating or reducing cardiovascular disease | APOB, GOT2, HDLBP | HMGCR 5/4885CYP3A4 1407/4885LMNA 1918/4885 |
| US-20090043115-A1 | Process for Producing Simvastatin | HMGCR, PCSK9, CETP | HMGCR 1/4885CYP3A4 30/4885LMNA 334/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.