Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 5/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 3/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.31 |
| ▸ | PRKACA | P17612 | 1/20 | 0.31 |
| ▸ | CASP6 | P55212 | 1/20 | 0.31 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.30 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.30 |
| ▸ | RAB9A | P51151 | 2/20 | 0.30 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.30 |
| ▸ | RELA | Q04206 | 2/20 | 0.30 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2579330 | 0.94 | MEN1 (0.34) | MEN1KMT2ASMN1; SMN2LMNAPKM | |
| SCHEMBL2578209 | 0.88 | SMN1; SMN2 (0.38) | MEN1KMT2ASMN1; SMN2LMNAPKM | |
| SCHEMBL23165184 | 0.82 | KEAP1 (0.38) | MEN1KMT2ASMN1; SMN2LMNANPC1 | |
| SCHEMBL29627176 | 0.82 | KEAP1 (0.38) | MEN1KMT2ASMN1; SMN2LMNANPC1 | |
| SCHEMBL18131220 | 0.79 | NPC1 (0.32) | NPC1 | |
| SCHEMBL23164955 | 0.78 | ERN1 (0.40) | MEN1KMT2ASMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL18131171 | 0.74 | L3MBTL1 (0.32) | KMT2ASMN1; SMN2ALDH1A1MAPTNPC1 | |
| SCHEMBL20028437 | 0.74 | NPC1 (0.37) | SMN1; SMN2ALDH1A1MAPTMAPK1NPC1 | |
| SCHEMBL27145505 | 0.74 | NPC1 (0.33) | MEN1KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL23166852 | 0.74 | RIPK1 (0.43) | MEN1KMT2ASMN1; SMN2LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4833078-B2 | — | — | 2011-12-07 | — | — | JP | claimed |
| EP-1689720-A1 | PYRAZOLYL DERIVATIVES IN THE FORM OF DRUGS FOR TREATING ACUTE OR CHRONIC NEURONAL REGRESSIONS | Aventis Pharma S.A. (FR) | 2006-08-16 | — | — | EP | claimed |
| WO-2005051917-A1 | PYRAZOLYL DERIVATIVES IN THE FORM OF DRUGS FOR TREATING ACUTE OR CHRONIC NEURONAL REGRESSIONS | AVENTIS PHARMA S.A. (FR) | 2005-06-09 | — | — | WO | claimed |