Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 12/20 | 0.65 |
| ▸ | MAOA | P21397 | 3/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | PTPRC | P08575 | 1/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6158837 | 0.87 | ALDH1A1 (0.54) | MAOBMAOAALDH1A1LMNAPTPRC | |
| SCHEMBL31123658 | 0.86 | ALDH1A1 (0.60) | ALDH1A1LMNASMN1; SMN2PTPRCPTPN1 | |
| SCHEMBL15286510 | 0.85 | ALDH1A1 (0.51) | MAOBALDH1A1LMNAL3MBTL1SMN1; SMN2 | |
| SCHEMBL3134818 | 0.84 | SLC6A3 (0.52) | MAOBALDH1A1LMNAL3MBTL1SMN1; SMN2 | |
| SCHEMBL5989500 | 0.84 | NPC1 (0.56) | ALDH1A1LMNAL3MBTL1SMN1; SMN2HTT | |
| SCHEMBL7820018 | 0.83 | MAPT (0.61) | MAOBMAOAALDH1A1LMNAL3MBTL1 | |
| SCHEMBL13870529 | 0.82 | OPRL1 (0.50) | ALDH1A1LMNASMN1; SMN2PTPN1MAPT | |
| SCHEMBL9450116 | 0.81 | HIF1A (0.69) | MAOBMAOAALDH1A1L3MBTL1SMN1; SMN2 | |
| SCHEMBL30746040 | 0.81 | HIF1A (0.69) | MAOBMAOAALDH1A1L3MBTL1SMN1; SMN2 | |
| SCHEMBL3995720 | 0.81 | TSHR (0.50) | ALDH1A1LMNASMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0729465-B1 | PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS | PARKE DAVIS & CO (US) | 2003-01-22 | — | — | EP | disclosed |
| US-6005103-A | TREATMENT OF BACTERIAL AND VIRAL INFECTIONS AND DISEASES, INCLUDING AIDS | WARNER-LAMBERT COMPANY (US) | 1999-12-21 | — | — | US | disclosed |
| US-5808062-A | AIDS THERAPY | WARNER-LAMBERT COMPANY (US) | 1998-09-15 | — | — | US | disclosed |
| EP-0729465-A1 | PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS | PARKE, DAVIS & COMPANY (US) | 1996-09-04 | — | — | EP | disclosed |
| EP-0729466-A1 | PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS | PARKE, DAVIS & COMPANY (US) | 1996-09-04 | — | — | EP | disclosed |
| WO-1995014013-A1 | PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS | PARKE, DAVIS & COMPANY (US) | 1995-05-26 | — | — | WO | disclosed |
| WO-1995014014-A2 | PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS | PARKE, DAVIS & COMPANY (US) | 1995-05-26 | — | — | WO | disclosed |